Organoids—three-dimensional structures derived from stem cells—are transforming biomedical research by modeling key aspects of human physiology and disease. By replicating native tissue architecture, cellular heterogeneity, and functional behavior, they provide human-relevant systems that address limitations inherent to conventional in-vitro and animal models.
Diabetes and cardiovascular disease are deeply interconnected conditions, characterized by shared, multi-organ pathophysiology. Organoid technologies offer unique opportunities to dissect disease mechanisms, evaluate therapeutic strategies, and develop personalized, physiologically relevant models. These systems enable the investigation of cardiometabolic processes in platforms that better reflect the complexity and progression of human disease.
Cardiovascular Diabetology welcomes original research articles, reviews, and meta-analyses for this Collection, which aims to highlight the use of organoid technologies in advancing our understanding of cardiovascular complications associated with diabetes.
Areas of interest include, but are not limited to:
- Organoid models of diabetic cardiomyopathy and heart failure
- Matrigel alternatives for organoid development
- Cell-cell and extracellular matrix interactions in organoids
- Organoid-based drug testing for cardiovascular diseases
- Organoid-on-chip systems for tissue crosstalk and perfusion3D bioprinting and tissue engineering for cardiovascular organoids
- Artificial intelligence–driven analysis of organoid function and phenotypes
- Organoid models of gestational diabetes–induced congenital heart disease
- Functional genomics using CRISPR in cardiovascular organoids
- Single-cell and spatial omics to map disease states in organoids
- Co-culture systems of vascular and pancreatic organoids to study metabolic-vascular crosstalk
- Organoid-based screening platforms for anti-diabetic and cardioprotective drugs
Submissions that contribute to conceptual clarity (e.g., distinctions between organoids and spheroids), incorporate multi-organ or metabolic system perspectives, or connect technological development with clinical or translational insights are especially welcome.
