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Structure genomics of SARS-CoV-2 and its Omicron variant

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update

Wei-long Wu
Xiao-xi Gong
Yan Wang

Review Article 19 May 2025

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Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth

Xiao-man Wei
Si-cheng Lu
Hai-bo Cheng
ArticleOpen Access20 May 2025
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates

Jing-hong Chen
Ke-xin Li
Peng Luo
ArticleOpen Access15 Apr 2025
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma

Jun-ying Wang
Meng-ping Chen
Jian Hou
ArticleOpen Access14 Apr 2025
Dehydrotrametenolic acid methyl ester, a triterpenoid of Poria cocos, alleviates non-alcoholic steatohepatitis by suppressing NLRP3 inflammasome activation via targeting Caspase-1 in mice

Ling-yan Xia
Nai-rong Yu
Ying Leng
Article06 May 2025

Current issue

Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets

Xiao-die Gao
Jian-e Ding
Hua-min Xu
Review Article11 Mar 2025
Targeting cholesterol metabolism: a promising therapy strategy for cancer

Chun-lan Dai
Zi-yang Qiu
Xin Luan
Review Article25 Mar 2025
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice

Ting-ting Li
Xiao-fan Guo
Zhen Wang
Article12 Mar 2025
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism

Li-da Du
Cheng Fang
Yin-zhong Ma
Article11 Mar 2025
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation

Meng-lu Song
Yun-yun Sun
Hua Yang
Article14 Mar 2025
Huperzine A attenuates epileptic seizures via enhancing dCA1-projecting septal cholinergic transmission

Yu Wang
Ke-yu Hu
Zhong Chen
Article26 Mar 2025

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Editorial Excellence

Acta Pharmacologica Sinica, among the top 25% qualifying journals, is recognized for its exceptional editorial excellence, based on data collected from the 2024 Journal Author Satisfaction survey. Congratulations to the Acta Pharmacologica Sinica editors!

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GRK2 dysfunction mediates acute kidney injury in murine administered methotrexate combined with omeprazole

Xiao Wei
Jun Yu
Yong-gui Wu
Article30 Jul 2025
circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis

Hua-yan Wu
Chuan-meng Zhou
Zhi-xin Shan
Article28 Jul 2025
Copper pyrithione, a copper complex ATG4B and autophagy inhibitor, exhibits potent anticancer effects

Peng-fei Qiang
Yao Wang
Yuan-yuan Fu
Article28 Jul 2025
Uricolysis by Arthrobacter globiformis uricase: structural basis for its catalytic activity and thermostability

Lu-nan Lv
Shi-jia Zu
Wei Fu
Article28 Jul 2025
Programmed sequential nanostructural conversion at nano-bio interface for synergistic cancer phototheranostics

Shi Sun
Rui Wang
Xian-feng Zhou
Article25 Jul 2025
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway

Qian Meng
Meng-hui Guo
Wei Wei
Article21 Jul 2025
Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment

Bin Lu
Yi-yun Sun
Bo Yang
Article17 Jul 2025
Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation

Mei-jie Chen
Zhi-dan Zhang
Suo-wen Xu
Correspondence16 Jul 2025
Senkyunolide A ameliorates cholestatic liver fibrosis by controlling CLCC1-mediated endoplasmic reticulum Ca²⁺ release

Ya-jing Li
Meng-yu Guo
Xiao-jiao-yang Li
Article15 Jul 2025

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Postdoc opportunity to engage in both foundational machine learning research and high-impact interdisciplinary applications in the life sciences.

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Shenzhen Medical Academy of Research and Translation
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Shenzhen, Guangdong (CN)

Shenzhen Medical Academy of Research and Translation
Tenure Track Faculty - Assistant or Associate Professor

The Carol and Gene Ludwig Program for the Study of Neuroimmune Interactions in Dementia at Yale School of Medicine seeks new tenure-track faculty.

New Haven, Connecticut

Yale School of Medicine - Ludwig Program for the Study of Neuroimmune Interaction in Dementia
Faculty Positions Open, ShanghaiTech University

6 major schools are now hiring faculty members.

Shanghai, China

ShanghaiTech University

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update

Featured

Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth

Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates

Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma

Dehydrotrametenolic acid methyl ester, a triterpenoid of Poria cocos, alleviates non-alcoholic steatohepatitis by suppressing NLRP3 inflammasome activation via targeting Caspase-1 in mice

Current issue

Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets

Targeting cholesterol metabolism: a promising therapy strategy for cancer

Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice

MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism

p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation

Huperzine A attenuates epileptic seizures via enhancing dCA1-projecting septal cholinergic transmission

Announcements

Editorial Excellence

Browse articles

GRK2 dysfunction mediates acute kidney injury in murine administered methotrexate combined with omeprazole

circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis

Copper pyrithione, a copper complex ATG4B and autophagy inhibitor, exhibits potent anticancer effects

Uricolysis by Arthrobacter globiformis uricase: structural basis for its catalytic activity and thermostability

Programmed sequential nanostructural conversion at nano-bio interface for synergistic cancer phototheranostics

G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway

Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment

Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation

Senkyunolide A ameliorates cholestatic liver fibrosis by controlling CLCC1-mediated endoplasmic reticulum Ca²⁺ release

Trending - Altmetric

Science jobs

Postdoctoral Researcher Position in Geometric Deep Learning & AI for Science (f/m/d)

Talent Recruitment of Postdoctoral Fellow, SMART

Open Positions at i-BRAIN

Tenure Track Faculty - Assistant or Associate Professor

Faculty Positions Open, ShanghaiTech University

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Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates

Widespread myocardial dysfunction in COVID-19 patients detected by myocardial strain imaging using 2-D speckle-tracking echocardiography

Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation

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