Supplementary Figure 2: ASD probands of European ancestry over-inherit ASD-associated polygenic risk. | Nature Genetics

Supplementary Figure 2: ASD probands of European ancestry over-inherit ASD-associated polygenic risk.

From: Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Supplementary Figure 2

We performed pTDT after restricting the cohort to European ancestry (Supplementary Note; n = 1,851 SSC probands, n = 3,209 PGC ASD probands, n = 5,060 SSC and PGC ASD probands combined, n = 1,509 SSC unaffected siblings). Transmission disequilibrium is shown in terms of standard deviations on mid-parent distribution ± 1.96 standard error (95% confidence interval). P values denote the probability that the mean of the pTDT deviation distribution is 0 (two-sided, one-sample t test).

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