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Survival-inferred fragility of statistical significance in phase III oncology trials

Alexander D. Sherry
Yufei Liu
Ethan B. Ludmir

Article 24 July 2025

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Multimodal prediction based on ultrasound for response to neoadjuvant chemotherapy in triple negative breast cancer

Maohua Lyu
Shouheng Yi
Zhenwei Shi
ArticleOpen Access25 Jul 2025
Gene- and immune-targeted therapy combinations using dual-matched biomarkers for patient selection

Daisuke Nishizaki
Razelle Kurzrock
Shumei Kato
ArticleOpen Access24 Jul 2025

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npj Precision Oncology has a 2-year impact factor of 7.9 (2022), article downloads of 543,359 (2022) and 8 days from submission to first editorial decision (2022).
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Browse articles

Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer

Nikki Salmond
Renata Moravcova
Karla C. Williams
ArticleOpen Access17 Oct 2025
Cytokine signaling and resistance to CDK4/6 inhibitors in HR⁺HER2⁻ breast cancer

While CDK4/6 inhibitors improved clinical outcomes in HR⁺HER2^- metastatic breast cancer (MBC), resistance invariably occurs. The underlying molecular mechanisms are not actionable, leaving limited therapeutic options for progressing patients. Recent data highlight a role for IL-6 in the resistance of HR⁺HER2^- MBC to CDK4/6 inhibition, potentially opening novel avenues forward.

Lukas Bolini
Joyce G. Habib
Lorenzo Galluzzi
CommentOpen Access16 Oct 2025
Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas

Petra Bullova
Peng Cui
Susanne Schlisio
ArticleOpen Access15 Oct 2025
RadGLO: an interactive platform for radiomic feature analysis and prognostic modeling in glioma

Kavita Kundal
K Divya Rani
Rahul Kumar
Brief CommunicationOpen Access14 Oct 2025
Prolonged response to dual immune checkpoint blockade in patients with advanced solid tumors: a case series

Camila B. Xavier
Mohamed A. Gouda
Apostolia M. Tsimberidou
Case ReportOpen Access09 Oct 2025
A large-scale, multi-centre validation study of an AI-empowered blood-based test for multi-cancer early detection

Yong Shen
Yong Xia
Mao Mao
ArticleOpen Access08 Oct 2025
Natural history of SPP1 signaling in NF1 tumors

Kimani Njoya
Huda Zayed
Daochun Sun
ArticleOpen Access06 Oct 2025
Pan cancer research reveals the role of PTGDS in tumor suppression and immune regulation

Jiajin Li
Zheng Qu
Shengbin Pei
ArticleOpen Access30 Sept 2025
Single-cell RNA-sequencing of BCG naïve and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM-mediated immune-suppressive pathway

Ivan Juric
Emily E. Fink
Byron H. Lee
ArticleOpen Access26 Sept 2025

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