JMIRx Bio

Spaceflight presents unique environmental stressors, such as microgravity and radiation, that significantly affect biological systems at the molecular, cellular, and organismal levels. Astronauts face an increased risk of developing cancer due to exposure to ionizing radiation and other spaceflight-related factors. Age plays a crucial role in the body’s response to the cellular stresses that lead to cancer, with younger organisms generally exhibiting more efficient response mechanisms than older ones. The vast majority of research investigating breast cancer risk from spaceflight uses cell lines exposed to simulated radiation and microgravity, but cell lines cannot capture the combinatorial response expressed across tissues, organs, and systems to real radiation and microgravity in space.

This is the author(s)' response to peer review reports related to "Machine Learning Ensemble Investigates Age in the Transcriptomic Response to Spaceflight in Murine Mammary Tissue: An Observational Study"

This is the author(s)' response to peer review reports related to "Relationship Between Seed Coat Color and Cytokinin Concentration in Efficiently Regenerating Leaf Lettuce Shoots: In Vitro Experimental Study"

This is a peer review report related to "Relationship Between Seed Coat Color and Cytokinin Concentration in Efficiently Regenerating Leaf Lettuce Shoots: In Vitro Experimental Study"

Lettuce (Lactuca sativa L.) is an economically important leafy vegetable that is cultivated worldwide. Advances in plant biotechnology have enabled the development of transgenic and transplastomic lettuce lines with specific agronomic traits that produce pharmaceutical proteins and biological compounds. Plant regeneration efficiency is a critical and highly cultivar-dependent step in plant genetic transformation. No morphological markers have been identified that predict the regeneration ability or cytokinin requirement in lettuce cultivars, hindering the establishment of efficient regeneration systems.

This is a peer review report related to "Relationship Between Seed Coat Color and Cytokinin Concentration in Efficiently Regenerating Leaf Lettuce Shoots: In Vitro Experimental Study"

This is a peer review report related to "Population interaction in the Jōmon society via three-dimensional data of human crania: Geometric morphometric study"

This is a peer review report related to "Population interaction in the Jōmon society via three-dimensional data of human crania: Geometric morphometric study"

This is the author(s)' response to peer review reports related to "Population interaction in the Jōmon society via three-dimensional data of human crania: Geometric morphometric study"

The Japanese archipelago during the Jōmon period (14,000 to 800 cal BC), when people engaged mainly in hunting and gathering and experienced relatively more severe climate changes, was an important prehistoric period for investigating how people reacted to environmental fluctuations in human evolutionary history. Anthropologists have extensively discussed the population history in the Jōmon period of the Japanese archipelago via their morphological variations. Some have supported the notion of relative morphological uniformity within the Jōmon population, which could be sustained by widespread population interactions, although others have claimed that spatiotemporal morphological differences (especially geographical clines) may exist to some extent.

This is the peer review related to “Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility (Preprint).”

Cholesterol biosynthesis is a critical pathway in cellular metabolism, with 3- hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) catalyzing its committed step. The inhibition of HMGR has been widely explored as a therapeutic target for managing hypercholesterolemia, and statins are the most commonly used competitive inhibitors. However, the search for novel, natural inhibitors of HMGR is still a vital area of research, especially in light of the adverse effects of the prolonged use of statins. Cochlospermum planchonii and Cochlospermum tinctorium are medicinal plants traditionally used in West Africa to treat metabolic disorders, including dyslipidemia, but the specific bioactive compounds responsible for these effects are currently poorly characterized.