BoGEMMS-HPC enables efficient large-scale simulations by integrating multi-threading and MPI-based parallelism, support for diverse input/output formats (FITS, SQLite, MongoDB), and runtime-configurable geometry and physics models. It builds on the Bologna Geant4 Multi-Mission Simulator (BoGEMMS) software architecture to deliver scalable and customizable simulations to support design, calibration, and data analysis of X-ray and gamma-ray observations.