People Spotlights
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- Altair Professor of Chemistry
Shu-ou Shan
The Shan lab integrates the approach of mechanistic enzymology with biophysical tools, including fluorescence spectroscopy, single molecule fluorescence microscopy, NMR, EPR, and cryo-EM, to decipher the molecular basis of diverse protein biogenesis pathways. ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ
- Mary and Charles Ferkel Professor of Chemistry and Biochemistry; Investigator, Howard Hughes Medical Institute
André Hoelz
The Hoelz lab carries out structure-function studies of the nuclear pore complex with the ultimate goal of elucidating the atomic structure of the NPC. The applied structure determination as well as the described design principles of the NPC may serve as paradigms for other macromolecular assemblies. ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤ
- Bren Professor of Biology and Chemistry; Merkin Institute Professor
Stephen Mayo
The focus of the Mayo lab is the coupling of theoretical, computational, and experimental techniques for the study of structural biology. In particular, they have placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy called "protein design automation." ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤ
- Arthur and Marian Hanisch Memorial Professor of Biochemistry
William M. (Bil) Clemons
Using approaches like X-ray crystallography, cryo-EM, biochemistry, and mass spectrometry, the Clemons lab seeks to resolve protein structures and interactions at the atomic level, providing fundamental insights into membrane protein assembly and function with broad implications for biology and drug discovery. ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ
- Assistant Professor of Biochemistry
Isaac Fianu
Using biochemistry, structural biology (especially cryo-EM), and related methods, the research in the Fianu lab aims to uncover how gene regulation works in health and disease. Ultimately, the goal is to understand the spatiotemporal control of gene expression and the coordination of genome-related processes—knowledge that may lead to new therapeutic strategies. ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤ
- Professor of Chemistry and Biology
Judith Campbell
The Campbell lab investigates how cells accurately replicate and repair their DNA to maintain genome stability. Her team focuses on the molecular mechanisms that process Okazaki fragments and resolve DNA replication stress, especially the roles of enzymes like DNA2 helicase/nuclease. Their work reveals how defects in these pathways contribute to genome instability and cancer, offering insight into potential therapeutic targets. ㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤ ㅤㅤㅤ ㅤㅤㅤ ㅤ