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March 2010; 2 (3)

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The Nuclear Envelope
- Martin W. Hetzer
Cold Spring Harb Perspect Biol March 2010;2:a000539 doi:10.1101/cshperspect.a000539
The nuclear envelope must break down each time a cell divides. Kinases such as Cdk1 help disassemble pore complexes, whereas microtubules generate forces that disrupt the membrane itself.
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Single-Molecule and Superresolution Imaging in Live Bacteria Cells
- Julie S. Biteen and
- W.E. Moerner
Cold Spring Harb Perspect Biol March 2010;2:a000448 doi:10.1101/cshperspect.a000448
Single-molecule imaging techniques now allow us to visualize the structure and behavior of signaling molecules, polarity proteins, and cytoskeletal components in live bacteria.
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The IKK Complex, a Central Regulator of NF-κB Activation
- Alain Israël
Cold Spring Harb Perspect Biol March 2010;2:a000158 doi:10.1101/cshperspect.a000158
The kinase IKK activates NF-κB signaling molecules by phosphorylating the inhibitor I-κB. New work reveals the roles of the three subunits of IKK and how it is regulated.
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Chromosome Territories
- Thomas Cremer and
- Marion Cremer
Cold Spring Harb Perspect Biol March 2010;2:a003889 doi:10.1101/cshperspect.a003889
Chromosomes occupy distinct territories in the cell nucleus. The major components of chromosome territories are chromatin domains separated by an interchromatin compartment.

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SLAM-Family Receptors: Immune Regulators with or without SAP-Family Adaptors
- André Veillette
Cold Spring Harb Perspect Biol March 2010;2:a002469 doi:10.1101/cshperspect.a002469
Signaling by SLAM receptors and associated SAP adapters promotes immune cell activation. Without SAPs, SLAMs instead generate inhibitory signals that suppress immune function.

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Clinical Outcomes and Correlates of TP53 Mutations and Cancer
- Ana I. Robles and
- Curtis C. Harris
Cold Spring Harb Perspect Biol March 2010;2:a001016 doi:10.1101/cshperspect.a001016
Methods from sequencing to functional assays can determine the status of the p53 pathway in tumors. These reveal different abnormalities that can be used as biomarkers for prognosis and therapy.
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Human Genetic Disorders of Axon Guidance
- Elizabeth C. Engle
Cold Spring Harb Perspect Biol March 2010;2:a001784 doi:10.1101/cshperspect.a001784
Mutations in axon guidance receptors, their ligands, and downstream signaling molecules lead to Duane syndrome and various other disorders characterized by errors in muscle innervation.

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Auxin and Monocot Development
- Paula McSteen
Cold Spring Harb Perspect Biol March 2010;2:a001479 doi:10.1101/cshperspect.a001479
Monocots and dicots share similar mechanisms for auxin biosynthesis, transport, and signaling, despite displaying big differences in the structures controlled by this phytohormone.
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Auxin Transporters—Why So Many?
- Eva Zažímalová,
- Angus S. Murphy,
- Haibing Yang,
- Klára Hoyerová,
- and Petr Hošek
Cold Spring Harb Perspect Biol March 2010;2:a001552 doi:10.1101/cshperspect.a001552
By using multiple transporters for the hormone auxin, plants can generate distinct hormonal responses to different stimuli and sustain high levels of auxin flow when needed.

Kang and Youngblood provide an overview of mechanisms during type 1 diabetes pathogenesis
Virginia Gao and colleagues on the gut–brain axis
Christine Klein and co-workers on the genetics of Parkinson’s disease