import.vcf
. The outputed list object has a different naming
scheme and different data formats. Previous data formats are still
supported by setting long.format
to TRUE
,
however the naming scheme is still changed.apply.polygenic.score
.
The expected default vcf.data
input format has changed. The
previous input format is still supported by setting
vcf.long.format
to TRUE
from the default
FALSE
.import.vcf
now
returns VCF data in a split format. A data.table
object
contains VCF data from fixed fields (CHROM, POS, ID, REF, ALT). A
matrix
object contains sample-specific genotypes in
allele-format in a sample (columns) by variant (rows) matrix.R CMD check
CI/CD action with
renv
dependency managementcreate.pgs.boxplot
assess.pgs.vcf.allele.match
to
condition the handling of ambiguous strand flips on the total number of
unambiguous strand flips.analyze.pgs.binary.predictiveness
which given a PGS and phenotypes runs a logistic regression and returns
statistics (OR, p-value, AUC) describing how well the PGS predicts the
phenotype. It also automatically plots a receiver-operator-curve.create.pgs.with.continuous.phenotype.plot
apply.polygenic.score