Font Manager allows you to disable fonts one at a time but there does not seem to be a way to disable a selection of fonts.

My Linux desktop has almost 300 fonts and I want to whittle it down to a dozen or so -- clicking each one will be tedious.

It would be nice to use Shift+click, Ctrl+click and Ctrl+A to create a selection and then enable/disable with a single click.

I considered editing ~/.config/fontconfig/fonts.conf (see https://askubuntu.com/a/1140105/318486) but that's also pretty daunting.

P.S. You can use Shift+click, Ctrl+click and Ctrl+A to multi-select font list items, but when you click the check-box only the clicked item gets disabled.

The screenshot in this 2009 post suggests that a multi-select disable once existed (https://forums.linuxmint.com/viewtopic.php?t=259109)