The aim of the study was to search for associations between plasma metabolite profiles and breast cancer risk in 1590 subjects from the E3N nested case-control study using 1H Nuclear Magnetic Resonance (NMR) untargeted metabolomics. The metabolism of breast cancer cases was more dysregulated at baseline in pre-menopausal than post-menopausal women, and higher plasma ethanol in cases suggested the involvement of alcohol intake.

(2) Jobard et al. (2021) Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case–control study nested within the French E3N cohort. British Journal of Cancer 2021 May 11; 124(10): 1734–1743.