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Description
Currently no specific support for somatic (or low grade mosaicism) mutations.
Solution:
Test default VIP on samples with known (ultra) low-grade mosaicism variants (somatic - oncology samples are the best).
If VIP is insufficient for this kind of data things to look into may include:
- The addition of a priori variants ( To add the possibility to detect previously detected variants)
- Same for known structural variants. ( You may want align reads to previously detected variant sequences specifically?)
- Gene panels (since the use of only a predetermined set of genes is practical/necessary)
Additional context
For future use in studies of (ultra) low-grade mosaicism (both cancer and rare-diseases).
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