diff --git a/CHANGELOG.md b/CHANGELOG.md
index be6d5820d7..856bc9a604 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,8 @@
 
 ### Template
 
+- Turn on automatic clean up of intermediate files in `work/` on successful pipeline completion in full-test config ([#2163](https://github.com/nf-core/tools/pull/2163))
+
 ### Linting
 
 ### Modules
diff --git a/nf_core/pipeline-template/conf/test_full.config b/nf_core/pipeline-template/conf/test_full.config
index d92692fa94..46b165a910 100644
--- a/nf_core/pipeline-template/conf/test_full.config
+++ b/nf_core/pipeline-template/conf/test_full.config
@@ -10,6 +10,8 @@
 ----------------------------------------------------------------------------------------
 */
 
+cleanup = true
+
 params {
     config_profile_name        = 'Full test profile'
     config_profile_description = 'Full test dataset to check pipeline function'