I created a lot of cmd and alt keybindings and used quite extensively. The reason being was apple's keyboard makes it easy to reach, especially right command.
Yet since moving into another job, I have to move into a more standard keyboard, start dealing with less reachable right ctrl/cmd and alt.
Moving forward, to the right way for productivity with versatility. I might consider the fact I need to compromise with multiple platforms and standard keyboards other than mac.