Just required a method to perceive the atom types and configure the atoms for a reaction.
There is a comparable method for IAtomContainers in AtomContainerManipulator.percieveAtomTypesAndConfigureAtoms(IAtomContainer container). However, I wasn't able to find a method that does this for all IAtomContainers in a reaction.
Should be straightforward to add such a method to ReactionManipulator.
I am happy to do this and open a PR if you agree.