I was getting the following error with no other output trying to launch VDesk after a Windows update.

Unable to load one or more of the requested types. Retrieve the LoaderExceptions property for more information

I "solved" it by changing the line containing <TargetFrameworkVersion>v4.7.1</TargetFrameworkVersion> to <TargetFrameworkVersion>v4.8</TargetFrameworkVersion> (line 12) in VDesk/VDesk.csproj and recompiling the code with msbuild. So it seems to be related to the .NET framework 4.7.1 not working anymore?

Edit: On Windows 10 build 19044.1862