Any thought to bringing out UART (maybe from an FTDI?) or USB hub to allow for external USB connections as well? I imagine this could be a very handy micro computer to carry around to be able to flash/reprogram/debug IoT/micro stuffs.

Something like this USB + Ethernet could be quite handy to have. Pull the case off and mount it bare PCB internally. Or perhaps this one is better, since it could go in a corner and provide 2 external USB, and 2 internal USB while still giving USB3.0 speeds.

Or actually this adafruit board is interesting, and it uses pogo-pins to 'takeover' the USB header output. At least of the Zero/Zero W, not sure on the Zero 2 W.