The simplest Bitcoin Core RPC library for when you just want to talk to Bitcoin Core.

If you started Bitcoin Core like this:

bitcoind -regtest -rpcuser=user -rpcpassword=pass

Instantiate the bitcoin_requests RPC client like this:

from bitcoin_requests import BitcoinRPC

rpc = BitcoinRPC('http://127.0.0.1:18443', 'user', 'pass')
blocks = rpc.generate(101)
tx = rpc.sendtoaddress(address, 20)

pip install bitcoin-requests