I am trying to follow the PTWAS tutorial/docs PTWAS_scan#1-ptwas-eqtl-weight-construction and was following through using the sufficient summary statistics (SSS). After this step with DAP-G on SSS there are no instructions or hints for what to do with the output and how to generate weights for this. Is it only possible to generate the eQTL weights using individual level data? If this is the case - how can one generate the sbams format? This does not appear to be documented anywhere, with only an indication of what the sbams file looks like? I would appreciate any advice on generating these eQTL weights if possible please? It would be great to see reproducible command line usage for how exactly PTWAS_scan.weights.hg38.txt.gz.tbi was generated. I think the relevant information available might be here: https://github.com/xqwen/dap/tree/master/gtex_v8_analysis to reproduce - but how might one use this to generate eQTL weights on ones own data (not GTEx v8 data)?
Many thanks