Abstract
Microbial polysaccharides are natural sources for intermolecular gel structures used in several fields such as food, pharmaceutical, cosmetics, and other industries owing to their advanced biological properties such as biocompatibility, biodegradability, and nontoxicity. They are produced by microbes such as bacteria, archaea and fungi as secondary metabolites for supporting cellular structure, sustaining cell metabolism, storing energy within the cell, host defense, cell-to-cell signaling, etc. Some microbial polysaccharides show anticancer, antioxidant, antimicrobial, and immunomodulatory activities. Bioactivities of microbial polysaccharides are affected by molecular weight, structure, monosaccharide composition, and functional groups. To enhance bioactivities of microbial polysaccharides, several modification methods are used such as physical and chemical cross-linking reactions. Xanthan gum, dextran, bacterial alginate, gellan gum, hyaluronic acid, curdlan, pullulan, and levan are some well-known microbial polysaccharides. Gelation of these microbial polysaccharides brings them several mechanical and biological properties which allow their use in biomedical applications. In this chapter, general information about microbial polysaccharides and gels, types of gels, characterization of gels, and gelling properties of microbial polysaccharides such as conditions of gel formation, physical properties, stability of polysaccharide gels, and biological properties were covered.
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References
Ahmad NH, Mustafa S, Man YBC. Microbial polysaccharides and their modification approaches: a review. Int J Food Prop. 2015;18:332–47. https://doi.org/10.1080/10942912.2012.693561.
Baby DK. Chapter 9: Rheology of hydrogels. In: Thomas S, Sarathchandran C, Chandran N, editors. Rheology of polymer blends and nanocomposites. Micro and nano technologies. Amsterdam: Elsevier; 2020. p. 193–204.
Banerjee S, Bhattacharya S. Food gels: gelling process and new applications. Crit Rev Food Sci Nutr. 2012;52:334–46. https://doi.org/10.1080/10408398.2010.500234.
Barcelos MCS, Vespermann KAC, Pelissari FM, Molina G. Current status of biotechnological production and applications of microbial exopolysaccharides. Crit Rev Food Sci Nutr. 2020;60:1475–95. https://doi.org/10.1080/10408398.2019.1575791.
Bueno VB, Bentini R, Catalani LH, et al. Synthesis and characterization of xanthan–hydroxyapatite nanocomposites for cellular uptake. Mater Sci Eng C. 2014;37:195–203. https://doi.org/10.1016/j.msec.2014.01.002.
Chaisuwan W, Jantanasakulwong K, Wangtueai S, et al. Microbial exopolysaccharides for immune enhancement: fermentation, modifications and bioactivities. Food Biosci. 2020;35:100564. https://doi.org/10.1016/j.fbio.2020.100564.
Choi W II, Hwang Y, Sahu A, et al. An injectable and physical Levan-based hydrogel as a dermal filler for soft tissue augmentation. Biomater Sci. 2018;6:2627–38.
Chung HJ, Park TG. Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering. Nano Today. 2009;4:429–37.
De Siqueira EC, de Souza RJ, Pinheiro IO, Formiga FR. Levan-based nanostructured systems: an overview. Int J Pharm. 2020;580:119242.
Demirci T, Hasköylü ME, Eroğlu MS, et al. Levan-based hydrogels for controlled release of Amphotericin B for dermal local antifungal therapy of Candidiasis. Eur J Pharm Sci. 2020;145:105255.
Ebara M, Kotsuchibashi Y, Uto K, et al. Smart hydrogels. Tokyo: Springer; 2014. p. 9–65.
Field CK, Kerstein MD. Overview of wound healing in a moist environment. Am J Surg. 1994;167:S2–6. https://doi.org/10.1016/0002-9610(94)90002-7.
Gentilini R, Munarin F, Bloise N, et al. Polysaccharide-based hydrogels with tunable composition as 3D cell culture systems. Int J Artif Organs. 2017;41:213–22. https://doi.org/10.5301/ijao.5000667.
Global Market Insights. Polymer gel market growth – industry size outlook report 2017–2024. Global Market Insights, Inc. 2020. https://www.gminsights.com/industry-analysis/polymer-gel-market. Accessed 17 July 2020.
Hu H, Xu FJ. Rational design and latest advances of polysaccharide-based hydrogels for wound healing. Biomater Sci. 2020;8:2084–101. https://doi.org/10.1039/d0bm00055h.
Hu W, Wang Z, Xiao Y, et al. Advances in crosslinking strategies of biomedical hydrogels. Biomater Sci. 2019;7:843–55. https://doi.org/10.1039/c8bm01246f.
Huettner N, Dargaville TR, Forget A. Discovering cell-adhesion peptides in tissue engineering: beyond RGD. Trends Biotechnol. 2018;36:372–83. https://doi.org/10.1016/j.tibtech.2018.01.008.
Jindal N, Singh Khattar J. Chapter 4: Microbial polysaccharides in food industry. In: Grumezescu AM, Holban AM (eds) Biopolymers for food design. Handbook of food bioengineering. London Academic; 2018. p. 95–123.
Jones OG, McClements DJ. Functional biopolymer particles: design, fabrication, and applications. Compr Rev Food Sci Food Saf. 2010;9:374–97. https://doi.org/10.1111/j.1541-4337.2010.00118.x.
Katzbauer B. Properties and applications of xanthan gum. Polym Degrad Stab. 1998;59:81–4. https://doi.org/10.1016/S0141-3910(97)00180-8.
Kim H-J, Decker EA, Julian McClements D. Preparation of multiple emulsions based on thermodynamic incompatibility of heat-denatured whey protein and pectin solutions. Food Hydrocoll. 2006;20:586–95. https://doi.org/10.1016/j.foodhyd.2005.06.007.
Kırtel O, Avşar G, Erkorkmaz BA, Öner ET. Microbial polysaccharides as food ingredients. In: Microbial production of food ingredients and additives. Elsevier; 2017. p. 347–83.
Kopeček J. Hydrogel biomaterials: a smart future? Biomaterials. 2007;28:5185–92. https://doi.org/10.1016/j.biomaterials.2007.07.044.
Kumar A, Rao KM, Han SS. Application of xanthan gum as polysaccharide in tissue engineering: a review. Carbohydr Polym. 2018;180:128–44. https://doi.org/10.1016/j.carbpol.2017.10.009.
Lin D, Kelly AL, Miao S. Preparation, structure-property relationships and applications of different emulsion gels: bulk emulsion gels, emulsion gel particles, and fluid emulsion gels. Trends Food Sci Technol. 2020;102:123–37. https://doi.org/10.1016/j.tifs.2020.05.024.
Mohammed ZH, Haque A, Richardson RK, Morris ER. Promotion and inhibition of xanthan “weak-gel” rheology by calcium ions. Carbohydr Polym. 2007;70:38–45. https://doi.org/10.1016/j.carbpol.2007.02.026.
Mondal S, Das S, Nandi AK. A review on recent advances in polymer and peptide hydrogels. Soft Matter. 2020;16:1404–54. https://doi.org/10.1039/c9sm02127b.
Moradali MF, Rehm BHA. Bacterial biopolymers: from pathogenesis to advanced materials. Nat Rev Microbiol. 2020;18:195–210. https://doi.org/10.1038/s41579-019-0313-3.
Morris ER, Nishinari K, Rinaudo M. Gelation of gellan – a review. Food Hydrocoll. 2012;28:373–411.
Mousavi S, Khoshfetrat AB, Khatami N, et al. Comparative study of collagen and gelatin in chitosan-based hydrogels for effective wound dressing: physical properties and fibroblastic cell behavior. Biochem Biophys Res Commun. 2019;518:625–31. https://doi.org/10.1016/j.bbrc.2019.08.102.
Nayak AK, Das B. Introduction to polymeric gels. In: Polymeric gels. Elsevier; 2018. p. 3–27.
Ng JY, Obuobi S, Chua ML, et al. Biomimicry of microbial polysaccharide hydrogels for tissue engineering and regenerative medicine – a review. Elsevier; 2020.
Öner ET, Hernández L, Combie J. Review of Levan polysaccharide: from a century of past experiences to future prospects. Biotechnol Adv. 2016;34:827–44. https://doi.org/10.1016/j.biotechadv.2016.05.002.
Porter NT, Martens EC. The critical roles of polysaccharides in gut microbial ecology and physiology. Annu Rev Microbiol. 2017;71:349–69.
Sharma S, Tiwari S. A review on biomacromolecular hydrogel classification and its applications. Int J Biol Macromol. 2020;162:737–47. https://doi.org/10.1016/j.ijbiomac.2020.06.110.
Slaughter BV, Khurshid SS, Fisher OZ, et al. Hydrogels in regenerative medicine. Adv Mater. 2009;21:3307–29.
Sun G, Mao JJ. Engineering dextran-based scaffolds for drug delivery and tissue repair. Nanomedicine. 2012;7:1771–84.
Tabernero A, Cardea S. Supercritical carbon dioxide techniques for processing microbial exopolysaccharides used in biomedical applications. Mater Sci Eng C. 2020;112:110940. https://doi.org/10.1016/j.msec.2020.110940.
Upadhyay R. Use of polysaccharide hydrogels in drug delivery and tissue engineering. Adv Tissue Eng Regen Med Open Access. 2017;2:145.
Ventura I, Jammal J, Bianco-Peled H. Insights into the nanostructure of low-methoxyl pectin–calcium gels. Carbohydr Polym. 2013;97:650–8. https://doi.org/10.1016/j.carbpol.2013.05.055.
Versluys M, Kirtel O, Toksoy Öner E, Van den Ende W. The Fructan syndrome: evolutionary aspects and common themes among plants and microbes. Plant Cell Environ. 2018;41:16–38.
Waffle L, Godin L, Harris LB, Kontopoulou M. Rheological and physical characteristics of crustal-scaled materials for centrifuge analogue modelling. J Struct Geol. 2016;86:181–99. https://doi.org/10.1016/j.jsg.2016.02.014.
Wu X, Zha J, Koffas MA. Microbial production of bioactive chemicals for human health. Curr Opin Food Sci. 2020;32:9–16. https://doi.org/10.1016/j.cofs.2019.12.007.
Xiang J, Shen L, Hong Y. Status and future scope of hydrogels in wound healing: synthesis, materials and evaluation. Eur Polym J. 2020;130:109609. https://doi.org/10.1016/j.eurpolymj.2020.109609.
Xie J-H, Jin M-L, Morris GA, et al. Advances on bioactive polysaccharides from medicinal plants. Crit Rev Food Sci Nutr. 2016;56:S60–84.
Yang X, Li A, Li X, et al. An overview of classifications, properties of food polysaccharides and their links to applications in improving food textures. Trends Food Sci Technol. 2020;102:1–15. https://doi.org/10.1016/j.tifs.2020.05.020.
Zhang H, Zhang F, Yuan R. Chapter 13: Applications of natural polymer-based hydrogels in the food industry. In: Chen Y, editor. Hydrogels based on natural polymers. Amsterdam: Elsevier; 2020. p. 357–410.
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Akan, G., Oner, E.T. (2022). Gel Properties of Microbial Polysaccharides. In: Oliveira, J.M., Radhouani, H., Reis, R.L. (eds) Polysaccharides of Microbial Origin. Springer, Cham. https://doi.org/10.1007/978-3-030-42215-8_34
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DOI: https://doi.org/10.1007/978-3-030-42215-8_34
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