Fig. 2

The absence of CD14 restrains pulmonary inflammation induced by A. xylosoxidans. A. Macroscopic aspect of the lungs of mice infected with 2,0 × 10⁷ A. xylosoxidans at 3 d.p.i. showing the intensity of lung damage. B. Weight of the lungs of mice infected with A. xylosoxidans. C. Representative photomicrographs of the lung pneumonia of mice infected with A. xylosoxidans, stained with HE, at 100× (scale bar:100 µm) and 400× (scale bar: 50 µm, in inset) magnification. D. Percentage of inflamed area in the lungs of mice infected with A. xylosoxidans, analysis performed by ImageJ software. E. Total proteins in BALF of infected mice. A, B, E and F are representative of two independent experiments (n = 4–6), C, D are representative of one experiment (n = 4–6). Data were analyzed by one-way ANOVA with Tukey’s multiple comparisons test, and are expressed as mean ± s.e.m. *p < 0.05.* infected vs PBS, # Cd14.^−/− vs C57Bl/6