Overview
- A comprehensive, up-to date guide to sperm DNA and chromatic damage for the clinician treating the infertile male
- Sections cover sperm chromatin structure, lab evaluation of chromatin and DNA damage, biological and clinical factors, clinical studies on the utility of sperm DNA damage testing, and current treatment options
- An excellent resource for reproductive medicine and REI specialists, urologists and any professional working with the infertile male
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About this book
This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm.
We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.
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Table of contents (32 chapters)
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Front Matter
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Human Sperm Chromatin Structure
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Front Matter
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Laboratory Evaluation of Sperm Chromatin and DNA Damage
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Front Matter
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Etiology of Sperm DNA Damage: Biological and Clinical Factors
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Front Matter
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Editors and Affiliations
About the editors
Armand Zini, MD, FRCSC, Professor, Department of Surgery, Division of Urology, St. Mary’s Hospital Center, Montreal, Québec, Canada
Ashok Agarwal, PhD, HCLD, Professor, Lerner College of Medicine of Case Western Reserve University, Director, Andrology Center, Director, American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
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Bibliographic Information
Book Title: A Clinician's Guide to Sperm DNA and Chromatin Damage
Editors: Armand Zini, Ashok Agarwal
DOI: https://doi.org/10.1007/978-3-319-71815-6
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing AG 2018
Hardcover ISBN: 978-3-319-71814-9Published: 23 March 2018
Softcover ISBN: 978-3-030-10116-9Published: 26 January 2019
eBook ISBN: 978-3-319-71815-6Published: 05 March 2018
Edition Number: 1
Number of Pages: XIX, 605
Topics: Reproductive Medicine, Andrology, Endocrinology
Keywords
- Abortive apoptosis
- Antioxidant therapy
- Azoospermia
- Comet assay
- Cryopreservation
- Erectile dysfunction
- Gonadotropin
- ICSI
- Male infertility
- Oxidative stress
- PICSI-HA binding
- SCD assay
- SCS assay
- Semen analysis
- Sperm chromatin
- Sperm DNA damage
- Sperm nucleoproteins
- Testicular dysfunction
- TUNEL assay
- Varicocelectomy