Thanks to visit codestin.com
Credit goes to link.springer.com

Skip to main content
  • 1814 Accesses

Abstract

This case history aims to illustrate the treatment of hypothyroidism in pregnancy, in particular the recommendation for levothyroxine rather than triiodothyronine (T3) containing thyroid hormone replacement. It will then address the recommendation for iodine supplementation in pregnancy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+
from £29.99 /Month
  • Starting from 10 chapters or articles per month
  • Access and download chapters and articles from more than 300k books and 2,500 journals
  • Cancel anytime
View plans

Buy Now

Chapter
GBP 19.95
Price includes VAT (United Kingdom)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
GBP 79.50
Price includes VAT (United Kingdom)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
GBP 99.99
Price includes VAT (United Kingdom)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. de Escobar GM, Obregon MJ, del Rey FE. Maternal thyroid hormones early in pregnancy and fetal brain development. Best Pract Res Clin Endocrinol Metab. 2004;18(2):225–48.

    Article  PubMed  Google Scholar 

  2. Pop VJ, Brouwers EP, Vader HL, Vulsma T, van Baar AL, de Vijlder JJ. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin Endocrinol (Oxf). 2003;59(3):282–8.

    Article  Google Scholar 

  3. Li Y, Shan Z, Teng W, Yu X, Fan C, Teng X, et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30 months. Clin Endocrinol (Oxf). 2010;72(6):825–9.

    Article  CAS  Google Scholar 

  4. Henrichs J, Bongers-Schokking JJ, Schenk JJ, Ghassabian A, Schmidt HG, Visser TJ, et al. Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study. J Clin Endocrinol Metab. 2010;95(9):4227–34.

    Article  CAS  PubMed  Google Scholar 

  5. Pearce EN, Leung AM, Blount BC, Bazrafshan HR, He X, Pino S, et al. Breast milk iodine and perchlorate concentrations in lactating Boston-area women. J Clin Endocrinol Metab. 2007;92(5):1673–7.

    Article  CAS  PubMed  Google Scholar 

  6. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21(10):1081–125.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Endocrine Society, American Association of Clinical Endocrinologists, Asia & Oceania Thyroid Association, American Thyroid Association, European Thyroid Association, Latin American Thyroid Association. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. Thyroid. 2007;17(11):1159–67.

    Article  Google Scholar 

  8. Alexander EK, Marqusee E, Lawrence J, Jarolim P, Fischer GA, Larsen PR. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. N Engl J Med. 2004;351(3):241–9.

    Article  CAS  PubMed  Google Scholar 

  9. Panesar NS, Li CY, Rogers MS. Reference intervals for thyroid hormones in pregnant Chinese women. Ann Clin Biochem. 2001;38(Pt 4):329–32.

    Article  CAS  PubMed  Google Scholar 

  10. Leung AM, Pearce EN, Braverman LE. Iodine content of prenatal multivitamins in the United States. N Engl J Med. 2009;360(9):939–40.

    Article  CAS  PubMed  Google Scholar 

  11. Becker DV, Braverman LE, Delange F, Dunn JT, Franklyn JA, Hollowell JG, et al. Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association. Thyroid. 2006;16(10):949–51.

    Article  CAS  PubMed  Google Scholar 

  12. American College of Obstetrics and Gynecology. ACOG practice bulletin. Thyroid disease in pregnancy. Number 37, August 2002. American College of Obstetrics and Gynecology. Int J Gynaecol Obstet. 2002;79(2):171–80.

    Article  Google Scholar 

  13. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999;341(8):549–55.

    Article  CAS  PubMed  Google Scholar 

  14. Downing S, Halpern L, Carswell J, Brown RS. Severe maternal hypothyroidism corrected prior to the third trimester is associated with normal cognitive outcome in the offspring. Thyroid. 2012;22(6):625–30.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Raffaella M. Colzani M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Colzani, R.M. (2015). Hypothyroidism in Pregnancy. In: Davies, T. (eds) A Case-Based Guide to Clinical Endocrinology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2059-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-2059-4_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2058-7

  • Online ISBN: 978-1-4939-2059-4

  • eBook Packages: MedicineMedicine (R0)

Keywords

Publish with us

Policies and ethics