Cell Death Mechanisms in Cancer

This Collection focuses on the various and complex mechanisms of regulated cell death, a central theme in cancer development, progression, and treatment response. We invite submissions related to both traditional and emerging pathways, including apoptosis (programmed cell death involving caspases), autophagy (self-degradation of cellular components for survival or death), necrosis (uncontrolled cell lysis often linked to inflammation), necroptosis (programmed necrosis mediated by RIPK3 and MLKL), ferroptosis (iron-dependent lipid peroxidation-driven cell death), pyroptosis (inflammatory caspase-mediated lytic death), cuproptosis (copper-dependent death associated with mitochondrial stress), parthanatos (DNA damage-driven, PARP-mediated death), and anoikis (detachment-induced apoptosis which play a critical in metastasis).

Special attention will be given to translational and clinical studies, such as how these pathways influence tumor immune evasion, therapy resistance, and the development of novel targeted treatments.

Submissions may include original research, reviews, and clinical studies on how regulating these pathways can improve cancer outcomes.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email [email protected] or the Editor-in-Chief.