Thanks to visit codestin.com
Credit goes to link.springer.com

Skip to main content
Springer Nature Link
Log in
Menu
Find a journal Publish with us Track your research
Search
Cart
  1. Home
  2. Diabetologia
  3. Article

Serum immunoreactive insulin responses to a glucose load in Asian Indian and European Type 2 (non-insulin-dependent) diabetic patients and control subjects

  • Originals
  • Published: April 1986
  • Volume 29, pages 235–237, (1986)
  • Cite this article
Download PDF
Diabetologia Aims and scope Submit manuscript
Serum immunoreactive insulin responses to a glucose load in Asian Indian and European Type 2 (non-insulin-dependent) diabetic patients and control subjects
Download PDF
  • V. Mohan1,
  • P. S. Sharp1,
  • H. R. Cloke1,
  • J. M. Burrin1,
  • B. Schumer1 &
  • …
  • E. M. Kohner1 
  • 852 Accesses

  • 147 Citations

  • 3 Altmetric

  • Explore all metrics

Summary

The serum immunoreactive insulin response to an oral glucose load was estimated in 15 Asian Indian and 29 European non-diabetic subjects, and in 45 Asian Indian and 72 European Type 2 (non-insulin-dependent) diabetic patients. In the non-diabetic group, basal insulin values were higher in the Asian Indians than the Europeans (16.7 ± 3.0 vs. 6.9 ± 0.7 mU/l, p < 0.001), and remained higher throughout the glucose tolerance test. Total insulin response was also higher in the Asian Indians (p < 0.001), and linear regression analysis revealed basal insulin, body mass index and race to be important predictors of insulin response. Amongst the diabetic patients, basal insulin values were again higher in the Asian Indians compared with the Europeans (18.0±5.0 vs. 11.5±0.9 mU/l, p<0.05). Total insulin response was also greater (p < 0.01). Linear regression analysis revealed the basal insulin value to be the only significant predictor of insulin response. The results demonstrate higher insulin levels in Asian Indians than Europeans in both normal subjects and Type 2 diabetic subjects. The insulin response to a glucose load is also greater in the Asian Indians. In the control subjects, ethnic differences contribute to this response, whereas in the diabetic patients this is a function of the elevated basal insulin values of the Asian Indians.

Article PDF

Download to read the full article text

Similar content being viewed by others

Psychosocial factors and glycemic control in insulin-naïve and insulin-experienced people with type 2 diabetes: a path analysis model

Article 25 November 2017

Initiating or Switching to Insulin Degludec/Insulin Aspart in Adults with Type 2 Diabetes: A Real-World, Prospective, Non-interventional Study Across Six Countries

Article Open access 25 June 2022

Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes mellitus requiring insulin intensification—a randomized phase IV trial: Indian subpopulation analyses

Article 02 November 2015

Explore related subjects

Discover the latest articles, books and news in related subjects, suggested using machine learning.
  • Diabetes
  • Endocrinology
  • Endocrine System and Metabolic Diseases
  • Pre-diabetes
  • Type 2 diabetes
  • Type 1 Diabetes
Use our pre-submission checklist

Avoid common mistakes on your manuscript.

References

  1. Taylor R, Zimmet P (1983) Epidemiology of diabetes: migrant studies. In: Mann JI, Pyrola K, Teuscher A (eds) Diabetes in epidemiological perspective, Churchill Livingstone, New York, pp 58–77

    Google Scholar 

  2. Marine N, Edelstein O, Jackson WPU, Vinik AI (1969) Diabetes, hyperglycaemia and glycosuria among Indians, Malays and Africans (Bantus) in Cape Town, South Africa. Diabetes 18: 840–857

    Google Scholar 

  3. Mather HM, Keen H (1985) The Southall diabetes survey: prevalence of known diabetes in Asians and Europeans. Br Med J 291: 1081–1084

    Google Scholar 

  4. National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28: 1039–1057

    Google Scholar 

  5. Morgan CR, Lazarow A (1963) Immunoassay of Insulin: two antibody system. Plasma insulin levels of normal, subdiabetic and diabetic rats. Diabetes 12:115–126

    Google Scholar 

  6. Rimoin DL (1969) Ethnic variability in glucose tolerance and insulin secretion. Arch Intern Med 124: 695–700

    Google Scholar 

  7. Aronoff SL, Bennett PH, Gordon P, Rushforth N, Miller M (1977) Unexplained hyperinsulinemia in normal and ‘prediabetic’ Pima Indians compared with normal Caucasians. An example of racial differences in insulin secretion. Diabetes 26: 827–840

    Google Scholar 

  8. Strauss E, Nagulesparan M (1980) Hypergastrinemia in diabetic Pima Indians. Endocrinology 106 (Suppl 1): 105

    Google Scholar 

  9. Gingerich RL, Nagulesparan M, Benmon L, Dye ES, Bauman WA (1985) Pancreatic polypeptide in Pima Indians: the influence of obesity and diabetes. Metabolism 34: 25–29

    Google Scholar 

  10. Zimmet P, Whitehouse S, Kies J (1979) Ethnic variability in glucose tolerance in Polynesian and Micronesian subjects. Diabetes 28:624–628

    Google Scholar 

  11. Rubenstein AH, Seftel HC, Miller K, Bersohn I, Wright AD (1969) Metabolic responses to oral glucose in healthy white, Indian and African subjects. Br Med J 1: 748–751

    Google Scholar 

  12. Omar MAK, Asmal AC (1983) Insulin responses to oral glucose in young African and Indian non-insulin dependent diabetic patients in Natal. Trop Geog Med 35: 59–64

    Google Scholar 

  13. Mohan V, Snehalatha C, Ramachandran A, Jayashree R, Viswanathan (1984) C-peptide responses to glucose load in maturity onset diabetes of the young (MODY). Diabetes Care 8: 69–72

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Chemical Pathology, Royal Postgraduate Medical School and Hammersmith Hospital, London, UK

    V. Mohan, P. S. Sharp, H. R. Cloke, J. M. Burrin, B. Schumer & E. M. Kohner

Authors
  1. V. Mohan
    View author publications

    Search author on:PubMed Google Scholar

  2. P. S. Sharp
    View author publications

    Search author on:PubMed Google Scholar

  3. H. R. Cloke
    View author publications

    Search author on:PubMed Google Scholar

  4. J. M. Burrin
    View author publications

    Search author on:PubMed Google Scholar

  5. B. Schumer
    View author publications

    Search author on:PubMed Google Scholar

  6. E. M. Kohner
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mohan, V., Sharp, P.S., Cloke, H.R. et al. Serum immunoreactive insulin responses to a glucose load in Asian Indian and European Type 2 (non-insulin-dependent) diabetic patients and control subjects. Diabetologia 29, 235–237 (1986). https://doi.org/10.1007/BF00454882

Download citation

  • Received: 27 June 1985

  • Revised: 20 January 1986

  • Issue date: April 1986

  • DOI: https://doi.org/10.1007/BF00454882

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Keywords

  • IRI
  • Type 2 diabetes
  • Asian Indians
  • Europeans
  • ethnic variation
Use our pre-submission checklist

Avoid common mistakes on your manuscript.

Advertisement

Search

Navigation

  • Find a journal
  • Publish with us
  • Track your research

Discover content

  • Journals A-Z
  • Books A-Z

Publish with us

  • Journal finder
  • Publish your research
  • Language editing
  • Open access publishing

Products and services

  • Our products
  • Librarians
  • Societies
  • Partners and advertisers

Our brands

  • Springer
  • Nature Portfolio
  • BMC
  • Palgrave Macmillan
  • Apress
  • Discover
  • Your US state privacy rights
  • Accessibility statement
  • Terms and conditions
  • Privacy policy
  • Help and support
  • Legal notice
  • Cancel contracts here

132.145.61.108

Not affiliated

Springer Nature

© 2025 Springer Nature