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A simple and specific screen for benzodiazepine-like drugs

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Abstract

Naive, non-hungry, non-thirsty rats ingested inordinate amounts of a sweetened milk solution when given their first opportunity to drink the solution while under the influence of benzodiazepine drugs. Among many other drugs tested, only phenobarbital gave a similar, although clearly weaker, effect. The test provides a simple, rapid, sensitive, and specific screen for benzodiazepine-like drugs. The effects were interpreted in terms of these drugs overcoming (disinhibiting) a rat's natural aversion to an unfamiliar food substance without at the same time greatly sedating the animal.

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References

  • Barnett, S. A.: The rat: A study in behaviour. Chicago: Aldine 1963.

    Google Scholar 

  • Geller, I., Seifter, J.: The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat. Psychopharmacologia (Berl.) 1, 482–492 (1960).

    Google Scholar 

  • Hanson, H. M., Stone, C. A.: Animal techniques for evaluating antianxiety drugs. In: Nodine and Siegler (Eds.): Animal and clinical pharmacologic techniques in drug evaluation. Chicago: Year Book Medical Publishers 1964.

    Google Scholar 

  • Margules, D. L., Stein, L.: Neuroleptics vs. tranquilizers: Evidence from animal behavior studies of mode and site of action. In: Bente and Bradley (Eds.): Neuropsychopharmacology, vol. 5. Amsterdam: Elsevier 1967.

    Google Scholar 

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Poschel, B.P.H. A simple and specific screen for benzodiazepine-like drugs. Psychopharmacologia 19, 193–198 (1971). https://doi.org/10.1007/BF00402642

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  • DOI: https://doi.org/10.1007/BF00402642

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