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Update 2020: Management of Non-Small Cell Lung Cancer

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Abstract

The past decade has seen a revolution of new advances in the management of non-small cell lung cancer (NSCLC) with remarkable progresses in screening, diagnosis, and treatment. The advances in systemic treatment have been driven primarily by the development of molecularly targeted therapeutics, immune checkpoint inhibitors, and anti-angiogenic agents, all of which have transformed this field with significantly improved patient outcomes. This review will address updates in lung cancer screening, liquid biopsy, and immunotherapy in the front-line setting. We discuss recent advances and highlight the plethora of new approvals of molecular-targeted therapy for subgroups of NSCLC patients with sensitizing EGFR, ALK, ROS1, RET, BRAF V600E, MET, and NTRK alterations.

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Authors and Affiliations

  1. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA

    Mariam Alexander

  2. Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    So Yeon Kim & Haiying Cheng

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  2. So Yeon Kim
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Mariam Alexander and So Yeon Kim do not have any conflicts of interest to disclose. Haiying Cheng has received research funding from Genentech/Roche, Eisai, Spectrum, Regeneron, Bayer, and Vaccinex.

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Alexander, M., Kim, S.Y. & Cheng, H. Update 2020: Management of Non-Small Cell Lung Cancer. Lung 198, 897–907 (2020). https://doi.org/10.1007/s00408-020-00407-5

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