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Linkage disequilibrium in two European F2 flint maize populations under modified recurrent full-sib selection

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An Erratum to this article was published on 26 May 2007

Abstract

According to quantitative genetic theory, linkage disequilibrium (LD) can hamper the short- and long-term selection response in recurrent selection (RS) programs. We analyzed LD in two European flint maize populations, KW1265 × D146 (A × B) and D145 × KW1292 (C × D), under modified recurrent full-sib selection. Our objectives were to investigate (1) the decay of initial parental LD present in F2 populations by three generations of intermating, (2) the generation of new LD in four (A × B) and seven (C × D) selection cycles, and (3) the relationship between LD changes and estimates of the additive genetic variance. We analyzed the F2 and the intermated populations as well as all selection cycles with 104 (A × B) and 101 (C × D) simple sequence repeat (SSR) markers with a uniform coverage of the entire maize genome. The LD coefficient D and the composite LD measure Δ were estimated and significance tests for LD were performed. LD was reduced by intermating as expected from theory. A directional generation of negative LD between favorable alleles could not be observed during the selection cycles. However, considerable undirectional changes in D were observed, which we attributed to genetic sampling due to the finite population size used for recombination. Consequently, a long-term reduction of the additive genetic variance due to negative LD was not observed. Our experimental results support the hypothesis that in practical RS programs with maize, LD generated by selection is not a limiting factor for obtaining a high selection response.

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Acknowledgments

The present study was supported by a grant from the Deutsche Forschungsgemeinschaft, Grant No. FR 1615/1. The authors thank Dr. D. Klein and the staff of the Plant Breeding Research Station at Eckartsweier for conducting the field trials. We thank KWS SAAT AG and Pioneer Hi-Bred Northern Europe for their support with the SSR screening. We gratefully acknowledge Christine Beuter and Elisabeth Kokai-Kota for the technical assistance with the SSR analyses. The authors appreciate the editorial work of Dr. Jasmina Muminović, whose suggestions considerably improved the style of the manuscript.

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Authors and Affiliations

  1. Institute of Plant Breeding, Seed Science, and Population Genetics, University of Hohenheim, 70593, Stuttgart, Germany

    K. C. Falke, H. P. Maurer, A. E. Melchinger, C. Flachenecker & M. Frisch

  2. Institute for Crop Production and Grassland Research, University of Hohenheim, 70593, Stuttgart, Germany

    H.- P. Piepho

Authors
  1. K. C. Falke
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  2. H. P. Maurer
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  3. A. E. Melchinger
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  4. H.- P. Piepho
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  5. C. Flachenecker
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  6. M. Frisch
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Corresponding author

Correspondence to A. E. Melchinger.

Additional information

Communicated by M. Xu.

K.C. Falke and H.P. Maurer are contributed equally to the manuscript.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00122-007-0574-5

Electronic supplementary material

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122_2007_544_MOESM1_ESM.doc

Supplementary table 1 Modified Rogers’ distances (MRD) between generations and selection cycles based on SSR analyses for populations A × B (above diagonal) and C × D (below diagonal). (DOC 30 kb)

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Falke, K.C., Maurer, H.P., Melchinger, A.E. et al. Linkage disequilibrium in two European F2 flint maize populations under modified recurrent full-sib selection. Theor Appl Genet 115, 289–297 (2007). https://doi.org/10.1007/s00122-007-0544-y

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