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Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma

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Abstract

In patients with recurrent malignant glioma, treatment-related myelodysplastic syndrome (t-MDS) and acute leukemia are rare adverse effects because the median survival after relapse is limited. We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ). A cytogenetic study showed del (3)(q11.1). MDS was diagnosed 8.4 months after beginning TMZ. The disease rapidly evolved into acute leukemia within 1 month after the onset of MDS, and the patient died 1 month later during induction chemotherapy. The prognosis of t-MDS is generally poor. Considering the increasing use of TMZ, which is regarded as a drug with moderate toxicity, careful follow-up with routine blood testing is vital.

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Authors and Affiliations

  1. Department of Hematology–Oncology, Mackay Memorial Hospital, Taiwan

    Ying-Wen Su, Ming-Chih Chang & Ruey-Kuen Hsieh

  2. Mackay Junior College of Nursing, Tapei, Taiwan

    Ming-Chih Chang & Ming-Fu Chiang

  3. Department of Neurosurgery, Mackay Memorial Hospital, Taipei, Taiwan

    Ming-Fu Chiang

Authors
  1. Ying-Wen Su
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  2. Ming-Chih Chang
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  3. Ming-Fu Chiang
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  4. Ruey-Kuen Hsieh
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Correspondence to Ying-Wen Su.

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Su, YW., Chang, MC., Chiang, MF. et al. Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma. J Neurooncol 71, 315–318 (2005). https://doi.org/10.1007/s11060-004-2028-0

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