Gene targeting

Latest research

1. From endotypes to therapeutic targets: exploring the potential of precision treat-to-target approaches in primary Sjögren’s disease

   • Jiayang Jin
   • Yuebo Jin
   • Jing He

   in Clinical Rheumatology

   Article 18 October 2025

   

2. Association of genetic variants in m¹A modification core genes and neuroblastoma risk

   • Susu Jiang
   • Siqi Dong
   • Zhenjian Zhuo

   in BMC Cancer

   Article Open access 17 October 2025

   

3. Suppression of pentraxin 3 inhibits human osteosarcoma cell metastasis by repressing MAZ through STAT3 pathway

   • Chia-Hsuan Chou
   • Yi-Hsien Hsieh
   • Ko-Hsiu Lu

   in Cancer Cell International

   Article Open access 17 October 2025

   

4. Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study

   • Yixiang He
   • Wanjia Qiao
   • Wenji Wang

   in Journal of Orthopaedic Surgery and Research

   Article Open access 17 October 2025

   

5. A novel protein cRERE encoded by a circular RNA directly targets ERK signaling to alleviate chemotherapy-induced neuropathic pain

   • Jian-Bo Zhang
   • Zhong-Bao Zhao
   • Ting Xu

   in Cell Communication and Signaling

   Article Open access 17 October 2025

   

6. Lysine malonylation as a therapeutic target: implications for metabolic, inflammatory, and oncological disorders

   • Ahsanullah Unar

   in Amino Acids

   Article Open access 17 October 2025

   

7. Targeting metalloptosis in tumor therapy: from molecular mechanisms to application of metal nanoparticles

   • Jinxiang Wang
   • Qin Tian
   • Yihang Pan

   in Molecular Cancer

   Article Open access 16 October 2025

   

8. Targeting mitochondrial transporters and metabolic reprogramming for disease treatment

   • Mboneye Anselme
   • Huafeng He
   • Shilong Zhong

   in Journal of Translational Medicine

   Article Open access 16 October 2025

   

9. Engineered phage-silver nanoparticle complexes as a new tool for targeted therapies

   • Laura Maria De Plano
   • Dario Morganti
   • Sabrina Conoci

   in Scientific Reports

   Article Open access 16 October 2025

   

10. A Multi-omics Exploration Revealing SLIT2 as a Prime Therapeutic Target for Peripheral Facial Paralysis: Integrating Single-Cell Transcriptomics and Plasma Proteome Data

    • Yuchao Liu
    • Chunli Li
    • Pei Chen

    in Cellular and Molecular Neurobiology

    Article Open access 16 October 2025

    

11. Integrated bioinformatics and molecular docking ıdentify CCNB1, CDK1, and CYP1A2 as therapeutic targets of phytochemicals in hepatocellular carcinoma

    • Murat Isıyel
    • Hamid Ceylan
    • Yeliz Demir

    in Naunyn-Schmiedeberg's Archives of Pharmacology

    Article 16 October 2025

    

12. Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level

    • Diana D. Kang
    • Adam Marks
    • Abraham J. P. Teunissen

    in Nature Biomedical Engineering

    Article 16 October 2025

    

13. Dendritic cell-targeted liposomes for cancer immunotherapy via inhibition of aryl hydrocarbon receptor

    • Chen-Guang Zhang
    • Chen-Yun Yeh
    • Yungling Leo Lee

    in Journal of Nanobiotechnology

    Article Open access 15 October 2025

    

14. Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles

    • Shi-Kun Zhou
    • Jing-Tong Luo
    • Jun Wang

    in Nature Communications

    Article Open access 15 October 2025

    

15. Pathways to precision medicine in cervical cancer: a comprehensive review of small molecule inhibitors, biomarkers and computational approaches

    • Nandini Purohit
    • Yajushi Mishra
    • Reshma Murali

    in 3 Biotech

    Article 15 October 2025

    

16. Assessing the efficacy of targeted enrichment protocol in PGT-M applications: a comprehensive analysis

    • Evrim Unsal
    • Leyla Ozer
    • Suleyman Aktuna

    in Journal of Assisted Reproduction and Genetics

    Article 15 October 2025

    

17. Acknowledgement to Referees

    in Targeted Oncology

    Article 15 October 2025

18. CGRP-targeted therapeutics for migraine: a clinical trial landscape analysis

    • Jun Li
    • Liping Huang
    • Gang Wang

    in Journal of Translational Medicine

    Article Open access 15 October 2025

    

19. Perspectives on the FDA platform technology designation program for the approval of gene therapies: a Swiss multi-stakeholder exploratory interview study

    • Yi Han
    • Kelly E. Ormond

    in Orphanet Journal of Rare Diseases

    Article Open access 14 October 2025

20. CRISPRa restores a haploinsufficient neuronal sodium channel

    • Iris Marchal

    in Nature Biotechnology

    Article 14 October 2025