Next-generation sequencing

Latest research

1. ScalableAligner: a fast NGS mapping tool for shared-memory system

   • Deyou Tang
   • Jialang Liang
   • Qingwen Deng

   in CCF Transactions on High Performance Computing

   Article 18 October 2025

   

2. Diagnostic Performance of Metagenomic Next-Generation Sequencing (mNGS) and Culture in Infected Pancreatic Necrosis: A Systematic Review and Meta-Analysis

   • Aizaz Ali
   • Asad Iqbal Khattak
   • Emad Mansoor

   in Digestive Diseases and Sciences

   Article Open access 18 October 2025

   

3. Systematic benchmarking of high-throughput subcellular spatial transcriptomics platforms across human tumors

   • Pengfei Ren
   • Rui Zhang
   • Zexian Zeng

   in Nature Communications

   Article Open access 17 October 2025

   

4. Empowering low-crosstalk, dynamic-decision random access of DNA storage via 384-multiplexed nanopore signatures

   • Junyao Li
   • Xuyang Zhao
   • Yi Li

   in Nature Communications

   Article Open access 17 October 2025

   

5. Investigating the population structure of Moraxella catarrhalis using a cgMLST scheme and LIN code system

   • Iman Yassine
   • Keith A. Jolley
   • Angela B. Brueggemann

   in Nature Communications

   Article Open access 17 October 2025

   

6. Genotyping sequence-resolved copy number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes

   • Walfred Ma
   • Mark J. P. Chaisson

   in Nature Genetics

   Article Open access 17 October 2025

   

7. Locityper enables targeted genotyping of complex polymorphic genes

   • Timofey Prodanov
   • Elizabeth G. Plender
   • Tobias Marschall

   in Nature Genetics

   Article Open access 17 October 2025

   

8. Development of a TaqMan based real-time PCR assay for the detection of bovine ephemeral fever virus

   • Shivam Solanki
   • M. Manu
   • Kuldip Gupta

   in Molecular Biology Reports

   Article 17 October 2025

   

9. Recommendations for bioinformatics in clinical practice

   • Ksenia Lavrichenko
   • Emilie Sofie Engdal
   • Frederik Otzen Bagger

   in Genome Medicine

   Article Open access 17 October 2025

   

10. Novel multiplex family-wide PCR and Nanopore sequencing of amplicons (FP-NSA) approach for surveillance of influenza- and coronaviruses in humans and animals

    • Irene Kasindi Meki
    • Ki Bum Ahn
    • Charles Euloge Lamien

    in Genome Medicine

    Article Open access 17 October 2025

    

11. Gap-free telomere-to-telomere genome assembly of marbled flounder (Pseudopleuronectes yokohamae)

    • Weiwei Zheng
    • Aijun Cui
    • Yongjiang Xu

    in Scientific Data

    Article Open access 17 October 2025

    

12. Predicting sequence-specific amplification efficiency in multi-template PCR with deep learning

    • Andreas L. Gimpel
    • Bowen Fan
    • Robert N. Grass

    in Nature Communications

    Article Open access 16 October 2025

    

13. Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic

    • Jimin Park
    • Daniel E. Cook
    • Kishwar Shafin

    in Nature Biotechnology

    Article 16 October 2025

    

14. Improving somatic variant calling with long-read technologies and public datasets

    in Nature Biotechnology

    Article 16 October 2025

    

15. sCCIgen: a high-fidelity spatially resolved transcriptomics data simulator for cell–cell interaction studies

    • Xiaoyu Song
    • Joselyn C. Chavez-Fuentes
    • Guo-Cheng Yuan

    in Genome Biology

    Article Open access 15 October 2025

    

16. gReLU: a comprehensive framework for DNA sequence modeling and design

    • Avantika Lal
    • Laura Gunsalus
    • Gokcen Eraslan

    in Nature Methods

    Article Open access 15 October 2025

    

17. Germany’s national genomDE strategy

    • Andreas Till
    • Roman A. Siddiqui
    • Oliver Kohlbacher

    in Nature Medicine

    Article 15 October 2025

    

18. Balancing complexity in retrofitting: an opposition-based NSGA-III framework for time, cost, quality, energy, safety, environment, and client satisfaction

    • Miguel Villagómez-Galindo
    • Ana Beatriz Martínez-Valencia
    • T. C. Manjunath

    in Asian Journal of Civil Engineering

    Article 15 October 2025

    

19. Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels

    • Kyle T. Helzer
    • Marina N. Sharifi
    • Shuang G. Zhao

    in Nature Communications

    Article Open access 14 October 2025

    

20. Arachis ampelovirus 1, a novel ampelovirus infecting forage peanut

    • Caterynne Melo Kauffmann
    • Alessandra de Jesus Boari
    • Tatsuya Nagata

    in Archives of Virology

    Article 14 October 2025

    

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