P10s - at least the types I used to sell - are kind of a loose definition. The one you linked to has an integrated wifi controller configurable only by Windows software. Some have SPI, but the bare boards are often a parallel interface/protocol that's very sensitive to timing issues. Since the boards that hit the hobbyist retail stream are typically surplus, they can have high failure rates. There are single-colour P10s, RGB P10s, outdoor-rated P10s, ...

If you want something MicroPython compatible, Pimoroni's Interstate 75 W HUB75 driver board/displays might work. But they are not inexpensive and don't look weatherproof.

Fortunately, I don't need outdoor weather proofing. Just looking for ways to drive a larger LED display. P10 or such not even a requirement, just seemed like a possible option. I am tempted to just use a Pi Zero or such and a cheap monitor, the only issue with that, is that I kinda dig the long horizontal 'form' factor given this project will be a combination count down clock and marque announcement display use case.

Hum... chaining a couple of these might be way to go...
https://www.amazon.com/Full-Color-Panel-Display-HUB75/dp/B0CP6BRG59