diff --git a/src/coreclr/System.Private.CoreLib/src/System/Threading/Interlocked.CoreCLR.cs b/src/coreclr/System.Private.CoreLib/src/System/Threading/Interlocked.CoreCLR.cs
index 1bce1b45748c9d..93df3bdfed9fb0 100644
--- a/src/coreclr/System.Private.CoreLib/src/System/Threading/Interlocked.CoreCLR.cs
+++ b/src/coreclr/System.Private.CoreLib/src/System/Threading/Interlocked.CoreCLR.cs
@@ -48,8 +48,20 @@ public static long Decrement(ref long location) =>
         /// <returns>The original value of <paramref name="location1"/>.</returns>
         /// <exception cref="NullReferenceException">The address of location1 is a null pointer.</exception>
         [Intrinsic]
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static int Exchange(ref int location1, int value)
+        {
+#if TARGET_X86 || TARGET_AMD64 || TARGET_ARM64 || TARGET_RISCV64
+            return Exchange(ref location1, value); // Must expand intrinsic
+#else
+            if (Unsafe.IsNullRef(ref location1))
+                ThrowHelper.ThrowNullReferenceException();
+            return Exchange32(ref location1, value);
+#endif
+        }
+
         [MethodImpl(MethodImplOptions.InternalCall)]
-        public static extern int Exchange(ref int location1, int value);
+        private static extern int Exchange32(ref int location1, int value);
 
         /// <summary>Sets a 64-bit signed integer to a specified value and returns the original value, as an atomic operation.</summary>
         /// <param name="location1">The variable to set to the specified value.</param>
@@ -57,8 +69,20 @@ public static long Decrement(ref long location) =>
         /// <returns>The original value of <paramref name="location1"/>.</returns>
         /// <exception cref="NullReferenceException">The address of location1 is a null pointer.</exception>
         [Intrinsic]
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static long Exchange(ref long location1, long value)
+        {
+#if TARGET_AMD64 || TARGET_ARM64 || TARGET_RISCV64
+            return Exchange(ref location1, value); // Must expand intrinsic
+#else
+            if (Unsafe.IsNullRef(ref location1))
+                ThrowHelper.ThrowNullReferenceException();
+            return Exchange64(ref location1, value);
+#endif
+        }
+
         [MethodImpl(MethodImplOptions.InternalCall)]
-        public static extern long Exchange(ref long location1, long value);
+        private static extern long Exchange64(ref long location1, long value);
 
         /// <summary>Sets an object to the specified value and returns a reference to the original object, as an atomic operation.</summary>
         /// <param name="location1">The variable to set to the specified value.</param>
@@ -66,9 +90,18 @@ public static long Decrement(ref long location) =>
         /// <returns>The original value of <paramref name="location1"/>.</returns>
         /// <exception cref="NullReferenceException">The address of location1 is a null pointer.</exception>
         [Intrinsic]
-        [MethodImpl(MethodImplOptions.InternalCall)]
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
         [return: NotNullIfNotNull(nameof(location1))]
-        public static extern object? Exchange([NotNullIfNotNull(nameof(value))] ref object? location1, object? value);
+        public static object? Exchange([NotNullIfNotNull(nameof(value))] ref object? location1, object? value)
+        {
+            if (Unsafe.IsNullRef(ref location1))
+                ThrowHelper.ThrowNullReferenceException();
+            return ExchangeObject(ref location1, value);
+        }
+
+        [return: NotNullIfNotNull(nameof(location1))]
+        [MethodImpl(MethodImplOptions.InternalCall)]
+        private static extern object? ExchangeObject([NotNullIfNotNull(nameof(value))] ref object? location1, object? value);
 
         // The below whole method reduces to a single call to Exchange(ref object, object) but
         // the JIT thinks that it will generate more native code than it actually does.
@@ -84,7 +117,7 @@ public static long Decrement(ref long location) =>
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         public static T Exchange<T>([NotNullIfNotNull(nameof(value))] ref T location1, T value) where T : class? =>
             Unsafe.As<T>(Exchange(ref Unsafe.As<T, object?>(ref location1), value));
-        #endregion
+#endregion
 
         #region CompareExchange
         /// <summary>Compares two 32-bit signed integers for equality and, if they are equal, replaces the first value.</summary>
@@ -94,8 +127,20 @@ public static T Exchange<T>([NotNullIfNotNull(nameof(value))] ref T location1, T
         /// <returns>The original value in <paramref name="location1"/>.</returns>
         /// <exception cref="NullReferenceException">The address of <paramref name="location1"/> is a null pointer.</exception>
         [Intrinsic]
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static int CompareExchange(ref int location1, int value, int comparand)
+        {
+#if TARGET_X86 || TARGET_AMD64 || TARGET_ARM64 || TARGET_RISCV64
+            return CompareExchange(ref location1, value, comparand); // Must expand intrinsic
+#else
+            if (Unsafe.IsNullRef(ref location1))
+                ThrowHelper.ThrowNullReferenceException();
+            return CompareExchange32(ref location1, value, comparand);
+#endif
+        }
+
         [MethodImpl(MethodImplOptions.InternalCall)]
-        public static extern int CompareExchange(ref int location1, int value, int comparand);
+        private static extern int CompareExchange32(ref int location1, int value, int comparand);
 
         /// <summary>Compares two 64-bit signed integers for equality and, if they are equal, replaces the first value.</summary>
         /// <param name="location1">The destination, whose value is compared with <paramref name="comparand"/> and possibly replaced.</param>
@@ -104,8 +149,20 @@ public static T Exchange<T>([NotNullIfNotNull(nameof(value))] ref T location1, T
         /// <returns>The original value in <paramref name="location1"/>.</returns>
         /// <exception cref="NullReferenceException">The address of <paramref name="location1"/> is a null pointer.</exception>
         [Intrinsic]
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static long CompareExchange(ref long location1, long value, long comparand)
+        {
+#if TARGET_AMD64 || TARGET_ARM64 || TARGET_RISCV64
+            return CompareExchange(ref location1, value, comparand); // Must expand intrinsic
+#else
+            if (Unsafe.IsNullRef(ref location1))
+                ThrowHelper.ThrowNullReferenceException();
+            return CompareExchange64(ref location1, value, comparand);
+#endif
+        }
+
         [MethodImpl(MethodImplOptions.InternalCall)]
-        public static extern long CompareExchange(ref long location1, long value, long comparand);
+        private static extern long CompareExchange64(ref long location1, long value, long comparand);
 
         /// <summary>Compares two objects for reference equality and, if they are equal, replaces the first object.</summary>
         /// <param name="location1">The destination object that is compared by reference with <paramref name="comparand"/> and possibly replaced.</param>
@@ -114,9 +171,18 @@ public static T Exchange<T>([NotNullIfNotNull(nameof(value))] ref T location1, T
         /// <returns>The original value in <paramref name="location1"/>.</returns>
         /// <exception cref="NullReferenceException">The address of <paramref name="location1"/> is a null pointer.</exception>
         [Intrinsic]
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        [return: NotNullIfNotNull(nameof(location1))]
+        public static object? CompareExchange(ref object? location1, object? value, object? comparand)
+        {
+            if (Unsafe.IsNullRef(ref location1))
+                ThrowHelper.ThrowNullReferenceException();
+            return CompareExchangeObject(ref location1, value, comparand);
+        }
+
         [MethodImpl(MethodImplOptions.InternalCall)]
         [return: NotNullIfNotNull(nameof(location1))]
-        public static extern object? CompareExchange(ref object? location1, object? value, object? comparand);
+        private static extern object? CompareExchangeObject(ref object? location1, object? value, object? comparand);
 
         // Note that getILIntrinsicImplementationForInterlocked() in vm\jitinterface.cpp replaces
         // the body of the following method with the following IL:
@@ -136,8 +202,8 @@ public static T Exchange<T>([NotNullIfNotNull(nameof(value))] ref T location1, T
         /// <exception cref="NullReferenceException">The address of <paramref name="location1"/> is a null pointer.</exception>
         /// <typeparam name="T">The type to be used for <paramref name="location1"/>, <paramref name="value"/>, and <paramref name="comparand"/>. This type must be a reference type.</typeparam>
         [Intrinsic]
-        [return: NotNullIfNotNull(nameof(location1))]
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        [return: NotNullIfNotNull(nameof(location1))]
         public static T CompareExchange<T>(ref T location1, T value, T comparand) where T : class? =>
             Unsafe.As<T>(CompareExchange(ref Unsafe.As<T, object?>(ref location1), value, comparand));
         #endregion
@@ -160,12 +226,36 @@ public static long Add(ref long location1, long value) =>
             ExchangeAdd(ref location1, value) + value;
 
         [Intrinsic]
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        private static int ExchangeAdd(ref int location1, int value)
+        {
+#if TARGET_X86 || TARGET_AMD64 || TARGET_ARM64 || TARGET_RISCV64
+            return ExchangeAdd(ref location1, value); // Must expand intrinsic
+#else
+            if (Unsafe.IsNullRef(ref location1))
+                ThrowHelper.ThrowNullReferenceException();
+            return ExchangeAdd32(ref location1, value);
+#endif
+        }
+
         [MethodImpl(MethodImplOptions.InternalCall)]
-        private static extern int ExchangeAdd(ref int location1, int value);
+        private static extern int ExchangeAdd32(ref int location1, int value);
 
         [Intrinsic]
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        private static long ExchangeAdd(ref long location1, long value)
+        {
+#if TARGET_AMD64 || TARGET_ARM64 || TARGET_RISCV64
+            return ExchangeAdd(ref location1, value); // Must expand intrinsic
+#else
+            if (Unsafe.IsNullRef(ref location1))
+                ThrowHelper.ThrowNullReferenceException();
+            return ExchangeAdd64(ref location1, value);
+#endif
+        }
+
         [MethodImpl(MethodImplOptions.InternalCall)]
-        private static extern long ExchangeAdd(ref long location1, long value);
+        private static extern long ExchangeAdd64(ref long location1, long value);
         #endregion
 
         #region Read
diff --git a/src/coreclr/vm/comutilnative.cpp b/src/coreclr/vm/comutilnative.cpp
index 01fa3313065546..c016311cd62314 100644
--- a/src/coreclr/vm/comutilnative.cpp
+++ b/src/coreclr/vm/comutilnative.cpp
@@ -1490,14 +1490,10 @@ NOINLINE void GCInterface::GarbageCollectModeAny(int generation)
 
 #include <optsmallperfcritical.h>
 
-FCIMPL2(INT32,COMInterlocked::Exchange, INT32 *location, INT32 value)
+FCIMPL2(INT32,COMInterlocked::Exchange32, INT32 *location, INT32 value)
 {
     FCALL_CONTRACT;
 
-    if( NULL == location) {
-        FCThrow(kNullReferenceException);
-    }
-
     return InterlockedExchange((LONG *) location, value);
 }
 FCIMPLEND
@@ -1506,22 +1502,14 @@ FCIMPL2_IV(INT64,COMInterlocked::Exchange64, INT64 *location, INT64 value)
 {
     FCALL_CONTRACT;
 
-    if( NULL == location) {
-        FCThrow(kNullReferenceException);
-    }
-
     return InterlockedExchange64((INT64 *) location, value);
 }
 FCIMPLEND
 
-FCIMPL3(INT32, COMInterlocked::CompareExchange, INT32* location, INT32 value, INT32 comparand)
+FCIMPL3(INT32, COMInterlocked::CompareExchange32, INT32* location, INT32 value, INT32 comparand)
 {
     FCALL_CONTRACT;
 
-    if( NULL == location) {
-        FCThrow(kNullReferenceException);
-    }
-
     return InterlockedCompareExchange((LONG*)location, value, comparand);
 }
 FCIMPLEND
@@ -1530,10 +1518,6 @@ FCIMPL3_IVV(INT64, COMInterlocked::CompareExchange64, INT64* location, INT64 val
 {
     FCALL_CONTRACT;
 
-    if( NULL == location) {
-        FCThrow(kNullReferenceException);
-    }
-
     return InterlockedCompareExchange64((INT64*)location, value, comparand);
 }
 FCIMPLEND
@@ -1542,10 +1526,6 @@ FCIMPL2(LPVOID,COMInterlocked::ExchangeObject, LPVOID*location, LPVOID value)
 {
     FCALL_CONTRACT;
 
-    if( NULL == location) {
-        FCThrow(kNullReferenceException);
-    }
-
     LPVOID ret = InterlockedExchangeT(location, value);
 #ifdef _DEBUG
     Thread::ObjectRefAssign((OBJECTREF *)location);
@@ -1559,10 +1539,6 @@ FCIMPL3(LPVOID,COMInterlocked::CompareExchangeObject, LPVOID *location, LPVOID v
 {
     FCALL_CONTRACT;
 
-    if( NULL == location) {
-        FCThrow(kNullReferenceException);
-    }
-
     // <TODO>@todo: only set ref if is updated</TODO>
     LPVOID ret = InterlockedCompareExchangeT(location, value, comparand);
     if (ret == comparand) {
@@ -1579,10 +1555,6 @@ FCIMPL2(INT32,COMInterlocked::ExchangeAdd32, INT32 *location, INT32 value)
 {
     FCALL_CONTRACT;
 
-    if( NULL == location) {
-        FCThrow(kNullReferenceException);
-    }
-
     return InterlockedExchangeAdd((LONG *) location, value);
 }
 FCIMPLEND
@@ -1591,10 +1563,6 @@ FCIMPL2_IV(INT64,COMInterlocked::ExchangeAdd64, INT64 *location, INT64 value)
 {
     FCALL_CONTRACT;
 
-    if( NULL == location) {
-        FCThrow(kNullReferenceException);
-    }
-
     return InterlockedExchangeAdd64((INT64 *) location, value);
 }
 FCIMPLEND
diff --git a/src/coreclr/vm/comutilnative.h b/src/coreclr/vm/comutilnative.h
index 18c5238f17b7dd..2152d1f89b85b5 100644
--- a/src/coreclr/vm/comutilnative.h
+++ b/src/coreclr/vm/comutilnative.h
@@ -230,10 +230,10 @@ extern "C" uint64_t QCALLTYPE GCInterface_GetGenerationBudget(int generation);
 class COMInterlocked
 {
 public:
-        static FCDECL2(INT32, Exchange, INT32 *location, INT32 value);
-        static FCDECL2_IV(INT64,   Exchange64, INT64 *location, INT64 value);
-        static FCDECL3(INT32, CompareExchange,        INT32* location, INT32 value, INT32 comparand);
-        static FCDECL3_IVV(INT64, CompareExchange64,        INT64* location, INT64 value, INT64 comparand);
+        static FCDECL2(INT32, Exchange32, INT32 *location, INT32 value);
+        static FCDECL2_IV(INT64, Exchange64, INT64 *location, INT64 value);
+        static FCDECL3(INT32, CompareExchange32, INT32* location, INT32 value, INT32 comparand);
+        static FCDECL3_IVV(INT64, CompareExchange64, INT64* location, INT64 value, INT64 comparand);
         static FCDECL2(LPVOID, ExchangeObject, LPVOID* location, LPVOID value);
         static FCDECL3(LPVOID, CompareExchangeObject, LPVOID* location, LPVOID value, LPVOID comparand);
         static FCDECL2(INT32, ExchangeAdd32, INT32 *location, INT32 value);
diff --git a/src/coreclr/vm/ecalllist.h b/src/coreclr/vm/ecalllist.h
index 88d9b03adcbc8b..c174710f19720a 100644
--- a/src/coreclr/vm/ecalllist.h
+++ b/src/coreclr/vm/ecalllist.h
@@ -461,14 +461,14 @@ FCFuncStart(gInteropMarshalFuncs)
 FCFuncEnd()
 
 FCFuncStart(gInterlockedFuncs)
-    FCFuncElementSig("Exchange", &gsig_SM_RefInt_Int_RetInt, COMInterlocked::Exchange)
-    FCFuncElementSig("Exchange", &gsig_SM_RefLong_Long_RetLong, COMInterlocked::Exchange64)
-    FCFuncElementSig("Exchange", &gsig_SM_RefObj_Obj_RetObj, COMInterlocked::ExchangeObject)
-    FCFuncElementSig("CompareExchange", &gsig_SM_RefInt_Int_Int_RetInt, COMInterlocked::CompareExchange)
-    FCFuncElementSig("CompareExchange", &gsig_SM_RefLong_Long_Long_RetLong, COMInterlocked::CompareExchange64)
-    FCFuncElementSig("CompareExchange", &gsig_SM_RefObj_Obj_Obj_RetObj, COMInterlocked::CompareExchangeObject)
-    FCFuncElementSig("ExchangeAdd", &gsig_SM_RefInt_Int_RetInt, COMInterlocked::ExchangeAdd32)
-    FCFuncElementSig("ExchangeAdd", &gsig_SM_RefLong_Long_RetLong, COMInterlocked::ExchangeAdd64)
+    FCFuncElement("Exchange32", COMInterlocked::Exchange32)
+    FCFuncElement("Exchange64", COMInterlocked::Exchange64)
+    FCFuncElement("ExchangeObject", COMInterlocked::ExchangeObject)
+    FCFuncElement("CompareExchange32", COMInterlocked::CompareExchange32)
+    FCFuncElement("CompareExchange64", COMInterlocked::CompareExchange64)
+    FCFuncElement("CompareExchangeObject", COMInterlocked::CompareExchangeObject)
+    FCFuncElement("ExchangeAdd32", COMInterlocked::ExchangeAdd32)
+    FCFuncElement("ExchangeAdd64", COMInterlocked::ExchangeAdd64)
 FCFuncEnd()
 
 FCFuncStart(gJitInfoFuncs)