diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0eeb11eb2..74eff90d3 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,12 @@
 # Changelog
 
+## [2.8.0](https://github.com/googleapis/java-datastore/compare/v2.7.0...v2.8.0) (2022-06-09)
+
+
+### Features
+
+* support IN/NOT_IN/NOT_EQUAL operators ([#688](https://github.com/googleapis/java-datastore/issues/688)) ([f8a84ff](https://github.com/googleapis/java-datastore/commit/f8a84ffa6d743501f5cfb71ac271d8a9b764705c))
+
 ## [2.7.0](https://github.com/googleapis/java-datastore/compare/v2.6.0...v2.7.0) (2022-06-02)
 
 
diff --git a/README.md b/README.md
index cc6f5854f..3b3853f06 100644
--- a/README.md
+++ b/README.md
@@ -19,7 +19,7 @@ If you are using Maven with [BOM][libraries-bom], add this to your pom.xml file
     <dependency>
       <groupId>com.google.cloud</groupId>
       <artifactId>libraries-bom</artifactId>
-      <version>25.3.0</version>
+      <version>25.4.0</version>
       <type>pom</type>
       <scope>import</scope>
     </dependency>
@@ -41,7 +41,7 @@ If you are using Maven without BOM, add this to your dependencies:
 <dependency>
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-datastore</artifactId>
-  <version>2.6.0</version>
+  <version>2.7.0</version>
 </dependency>
 
 ```
@@ -49,20 +49,20 @@ If you are using Maven without BOM, add this to your dependencies:
 If you are using Gradle 5.x or later, add this to your dependencies
 
 ```Groovy
-implementation platform('com.google.cloud:libraries-bom:25.3.0')
+implementation platform('com.google.cloud:libraries-bom:25.4.0')
 
 implementation 'com.google.cloud:google-cloud-datastore'
 ```
 If you are using Gradle without BOM, add this to your dependencies
 
 ```Groovy
-implementation 'com.google.cloud:google-cloud-datastore:2.6.0'
+implementation 'com.google.cloud:google-cloud-datastore:2.7.0'
 ```
 
 If you are using SBT, add this to your dependencies
 
 ```Scala
-libraryDependencies += "com.google.cloud" % "google-cloud-datastore" % "2.6.0"
+libraryDependencies += "com.google.cloud" % "google-cloud-datastore" % "2.7.0"
 ```
 
 ## Authentication
diff --git a/datastore-v1-proto-client/pom.xml b/datastore-v1-proto-client/pom.xml
index d6dce089b..8dd942d71 100644
--- a/datastore-v1-proto-client/pom.xml
+++ b/datastore-v1-proto-client/pom.xml
@@ -19,12 +19,12 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.cloud.datastore</groupId>
   <artifactId>datastore-v1-proto-client</artifactId>
-  <version>2.7.0</version><!-- {x-version-update:datastore-v1-proto-client:current} -->
+  <version>2.8.0</version><!-- {x-version-update:datastore-v1-proto-client:current} -->
 
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-datastore-parent</artifactId>
-    <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+    <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
   </parent>
 
   <packaging>jar</packaging>
diff --git a/google-cloud-datastore-bom/pom.xml b/google-cloud-datastore-bom/pom.xml
index a1ec96109..f452f3022 100644
--- a/google-cloud-datastore-bom/pom.xml
+++ b/google-cloud-datastore-bom/pom.xml
@@ -3,7 +3,7 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-datastore-bom</artifactId>
-  <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore-bom:current} -->
+  <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore-bom:current} -->
   <packaging>pom</packaging>
   <parent>
     <groupId>com.google.cloud</groupId>
@@ -52,22 +52,22 @@
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>google-cloud-datastore</artifactId>
-        <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+        <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-cloud-datastore-admin-v1</artifactId>
-        <version>2.7.0</version><!-- {x-version-update:grpc-google-cloud-datastore-admin-v1:current} -->
+        <version>2.8.0</version><!-- {x-version-update:grpc-google-cloud-datastore-admin-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-datastore-v1</artifactId>
-        <version>0.98.0</version><!-- {x-version-update:proto-google-cloud-datastore-v1:current} -->
+        <version>0.99.0</version><!-- {x-version-update:proto-google-cloud-datastore-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-datastore-admin-v1</artifactId>
-        <version>2.7.0</version><!-- {x-version-update:proto-google-cloud-datastore-admin-v1:current} -->
+        <version>2.8.0</version><!-- {x-version-update:proto-google-cloud-datastore-admin-v1:current} -->
       </dependency>
     </dependencies>
   </dependencyManagement>
diff --git a/google-cloud-datastore/pom.xml b/google-cloud-datastore/pom.xml
index 47481a1a6..49778e706 100644
--- a/google-cloud-datastore/pom.xml
+++ b/google-cloud-datastore/pom.xml
@@ -2,7 +2,7 @@
 <project xmlns="http://maven.apache.org/POM/4.0.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://maven.apache.org/POM/4.0.0 http://maven.apache.org/xsd/maven-4.0.0.xsd">
   <modelVersion>4.0.0</modelVersion>
   <artifactId>google-cloud-datastore</artifactId>
-  <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+  <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
   <packaging>jar</packaging>
   <name>Google Cloud Datastore</name>
   <url>https://github.com/googleapis/java-datastore</url>
@@ -12,7 +12,7 @@
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-datastore-parent</artifactId>
-    <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+    <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
   </parent>
   <properties>
     <site.installationModule>google-cloud-datastore</site.installationModule>
diff --git a/google-cloud-datastore/src/main/java/com/google/cloud/datastore/StructuredQuery.java b/google-cloud-datastore/src/main/java/com/google/cloud/datastore/StructuredQuery.java
index 63318a090..8e50d0867 100644
--- a/google-cloud-datastore/src/main/java/com/google/cloud/datastore/StructuredQuery.java
+++ b/google-cloud-datastore/src/main/java/com/google/cloud/datastore/StructuredQuery.java
@@ -272,7 +272,10 @@ public Operator apply(String constant) {
       static final Operator GREATER_THAN = type.createAndRegister("GREATER_THAN");
       static final Operator GREATER_THAN_OR_EQUAL = type.createAndRegister("GREATER_THAN_OR_EQUAL");
       static final Operator EQUAL = type.createAndRegister("EQUAL");
+      static final Operator IN = type.createAndRegister("IN");
+      static final Operator NOT_EQUAL = type.createAndRegister("NOT_EQUAL");
       static final Operator HAS_ANCESTOR = type.createAndRegister("HAS_ANCESTOR");
+      static final Operator NOT_IN = type.createAndRegister("NOT_IN");
 
       com.google.datastore.v1.PropertyFilter.Operator toPb() {
         return com.google.datastore.v1.PropertyFilter.Operator.valueOf(name());
@@ -502,6 +505,46 @@ public static PropertyFilter eq(String property, Blob value) {
       return new PropertyFilter(property, Operator.EQUAL, of(value));
     }
 
+    public static PropertyFilter neq(String property, Value<?> value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, value);
+    }
+
+    public static PropertyFilter neq(String property, String value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, long value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, double value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, boolean value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, Timestamp value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, Key value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, Blob value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter in(String property, ListValue value) {
+      return new PropertyFilter(property, Operator.IN, value);
+    }
+
+    public static PropertyFilter not_in(String property, ListValue value) {
+      return new PropertyFilter(property, Operator.NOT_IN, value);
+    }
+
     public static PropertyFilter hasAncestor(Key key) {
       return new PropertyFilter(KEY_PROPERTY_NAME, Operator.HAS_ANCESTOR, of(key));
     }
diff --git a/google-cloud-datastore/src/test/java/com/google/cloud/datastore/it/ITDatastoreTest.java b/google-cloud-datastore/src/test/java/com/google/cloud/datastore/it/ITDatastoreTest.java
index 21acf598c..869984932 100644
--- a/google-cloud-datastore/src/test/java/com/google/cloud/datastore/it/ITDatastoreTest.java
+++ b/google-cloud-datastore/src/test/java/com/google/cloud/datastore/it/ITDatastoreTest.java
@@ -583,6 +583,83 @@ public void testRunStructuredQuery() throws InterruptedException {
     assertFalse(results4.hasNext());
   }
 
+  @Test
+  public void testInNotInNeqFilters() throws InterruptedException {
+    Entity e1 =
+        Entity.newBuilder(ENTITY1)
+            .setKey(Key.newBuilder(INCOMPLETE_KEY1, "e1").build())
+            .set("v_int", 10)
+            .build();
+    Entity e2 =
+        Entity.newBuilder(ENTITY1)
+            .setKey(Key.newBuilder(INCOMPLETE_KEY1, "e2").build())
+            .set("v_int", 20)
+            .build();
+    DATASTORE.put(e1, e2);
+
+    Query<Entity> queryIn =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.in("v_int", ListValue.of(10, 20)))
+            .build();
+
+    Query<Entity> scQueryIn =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.hasAncestor(ROOT_KEY))
+            .setFilter(PropertyFilter.in("v_int", ListValue.of(10, 20)))
+            .build();
+
+    Iterator<Entity> resultIn = getStronglyConsistentResults(scQueryIn, queryIn);
+
+    assertTrue(resultIn.hasNext());
+    assertEquals(e1, resultIn.next());
+    assertTrue(resultIn.hasNext());
+    assertEquals(e2, resultIn.next());
+    assertFalse(resultIn.hasNext());
+
+    Query<Entity> queryNotIn =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.not_in("v_int", ListValue.of(20, 30)))
+            .build();
+
+    Query<Entity> scQueryNotIn =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.hasAncestor(ROOT_KEY))
+            .setFilter(PropertyFilter.not_in("v_int", ListValue.of(20, 30)))
+            .build();
+
+    Iterator<Entity> resultNotIn = getStronglyConsistentResults(scQueryNotIn, queryNotIn);
+
+    assertTrue(resultNotIn.hasNext());
+    assertEquals(e1, resultNotIn.next());
+    assertFalse(resultNotIn.hasNext());
+
+    Query<Entity> queryNeq =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.neq("v_int", 10))
+            .build();
+
+    Query<Entity> scQueryNeq =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.hasAncestor(ROOT_KEY))
+            .setFilter(PropertyFilter.neq("v_int", 10))
+            .build();
+
+    Iterator<Entity> resultNeq = getStronglyConsistentResults(scQueryNeq, queryNeq);
+
+    assertTrue(resultNeq.hasNext());
+    assertEquals(e2, resultNeq.next());
+    assertFalse(resultNeq.hasNext());
+
+    DATASTORE.delete(e1.getKey());
+    DATASTORE.delete(e2.getKey());
+  }
+
   @Test
   public void testAllocateId() {
     KeyFactory keyFactory = DATASTORE.newKeyFactory().setKind(KIND1);
diff --git a/grpc-google-cloud-datastore-admin-v1/pom.xml b/grpc-google-cloud-datastore-admin-v1/pom.xml
index e5b1ba8c1..6e2eb88fd 100644
--- a/grpc-google-cloud-datastore-admin-v1/pom.xml
+++ b/grpc-google-cloud-datastore-admin-v1/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>grpc-google-cloud-datastore-admin-v1</artifactId>
-  <version>2.7.0</version><!-- {x-version-update:grpc-google-cloud-datastore-admin-v1:current} -->
+  <version>2.8.0</version><!-- {x-version-update:grpc-google-cloud-datastore-admin-v1:current} -->
   <name>grpc-google-cloud-datastore-admin-v1</name>
   <description>GRPC library for google-cloud-datastore</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-datastore-parent</artifactId>
-    <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+    <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/pom.xml b/pom.xml
index 7cd990fd3..b10de9616 100644
--- a/pom.xml
+++ b/pom.xml
@@ -4,7 +4,7 @@
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-datastore-parent</artifactId>
   <packaging>pom</packaging>
-  <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+  <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
   <name>Google Cloud Datastore Parent</name>
   <url>https://github.com/googleapis/java-datastore</url>
   <description>
@@ -159,27 +159,27 @@
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-datastore-admin-v1</artifactId>
-        <version>2.7.0</version><!-- {x-version-update:proto-google-cloud-datastore-admin-v1:current} -->
+        <version>2.8.0</version><!-- {x-version-update:proto-google-cloud-datastore-admin-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-cloud-datastore-admin-v1</artifactId>
-        <version>2.7.0</version><!-- {x-version-update:grpc-google-cloud-datastore-admin-v1:current} -->
+        <version>2.8.0</version><!-- {x-version-update:grpc-google-cloud-datastore-admin-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>google-cloud-datastore</artifactId>
-        <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+        <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-datastore-v1</artifactId>
-        <version>0.98.0</version><!-- {x-version-update:proto-google-cloud-datastore-v1:current} -->
+        <version>0.99.0</version><!-- {x-version-update:proto-google-cloud-datastore-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.cloud.datastore</groupId>
         <artifactId>datastore-v1-proto-client</artifactId>
-        <version>2.7.0</version><!-- {x-version-update:datastore-v1-proto-client:current} -->
+        <version>2.8.0</version><!-- {x-version-update:datastore-v1-proto-client:current} -->
         <exclusions>
           <exclusion>
             <groupId>com.google.api.grpc</groupId>
diff --git a/proto-google-cloud-datastore-admin-v1/pom.xml b/proto-google-cloud-datastore-admin-v1/pom.xml
index bc010fd3b..81fe70639 100644
--- a/proto-google-cloud-datastore-admin-v1/pom.xml
+++ b/proto-google-cloud-datastore-admin-v1/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>proto-google-cloud-datastore-admin-v1</artifactId>
-  <version>2.7.0</version><!-- {x-version-update:proto-google-cloud-datastore-admin-v1:current} -->
+  <version>2.8.0</version><!-- {x-version-update:proto-google-cloud-datastore-admin-v1:current} -->
   <name>proto-google-cloud-datastore-admin-v1</name>
   <description>Proto library for google-cloud-datastore</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-datastore-parent</artifactId>
-    <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+    <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/proto-google-cloud-datastore-v1/pom.xml b/proto-google-cloud-datastore-v1/pom.xml
index e88bf74b0..2cd67b83c 100644
--- a/proto-google-cloud-datastore-v1/pom.xml
+++ b/proto-google-cloud-datastore-v1/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>proto-google-cloud-datastore-v1</artifactId>
-  <version>0.98.0</version><!-- {x-version-update:proto-google-cloud-datastore-v1:current} -->
+  <version>0.99.0</version><!-- {x-version-update:proto-google-cloud-datastore-v1:current} -->
   <name>proto-google-cloud-datastore-v1</name>
   <description>PROTO library for proto-google-cloud-datastore-v1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-datastore-parent</artifactId>
-    <version>2.7.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
+    <version>2.8.0</version><!-- {x-version-update:google-cloud-datastore:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/samples/install-without-bom/pom.xml b/samples/install-without-bom/pom.xml
index bd84bbd28..e410952e4 100644
--- a/samples/install-without-bom/pom.xml
+++ b/samples/install-without-bom/pom.xml
@@ -29,7 +29,7 @@
     <dependency>
       <groupId>com.google.cloud</groupId>
       <artifactId>google-cloud-datastore</artifactId>
-      <version>2.6.0</version>
+      <version>2.7.0</version>
     </dependency>
     <!-- [END datastore_install_without_bom] -->
 
diff --git a/samples/native-image-sample/pom.xml b/samples/native-image-sample/pom.xml
index 93eb45f2b..7e9801d03 100644
--- a/samples/native-image-sample/pom.xml
+++ b/samples/native-image-sample/pom.xml
@@ -28,7 +28,7 @@
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>libraries-bom</artifactId>
-        <version>25.3.0</version>
+        <version>25.4.0</version>
         <type>pom</type>
         <scope>import</scope>
       </dependency>
diff --git a/samples/snapshot/pom.xml b/samples/snapshot/pom.xml
index fa891d634..0643927f1 100644
--- a/samples/snapshot/pom.xml
+++ b/samples/snapshot/pom.xml
@@ -28,7 +28,7 @@
     <dependency>
       <groupId>com.google.cloud</groupId>
       <artifactId>google-cloud-datastore</artifactId>
-      <version>2.6.0</version>
+      <version>2.7.0</version>
     </dependency>
 
     <dependency>
diff --git a/samples/snippets/pom.xml b/samples/snippets/pom.xml
index 0df17e88b..720a81c88 100644
--- a/samples/snippets/pom.xml
+++ b/samples/snippets/pom.xml
@@ -30,7 +30,7 @@
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>libraries-bom</artifactId>
-        <version>25.3.0</version>
+        <version>25.4.0</version>
         <type>pom</type>
         <scope>import</scope>
       </dependency>
diff --git a/versions.txt b/versions.txt
index 9db4188a8..9e1dc1b27 100644
--- a/versions.txt
+++ b/versions.txt
@@ -1,9 +1,9 @@
 # Format:
 # module:released-version:current-version
 
-google-cloud-datastore:2.7.0:2.7.0
-google-cloud-datastore-bom:2.7.0:2.7.0
-proto-google-cloud-datastore-v1:0.98.0:0.98.0
-datastore-v1-proto-client:2.7.0:2.7.0
-proto-google-cloud-datastore-admin-v1:2.7.0:2.7.0
-grpc-google-cloud-datastore-admin-v1:2.7.0:2.7.0
+google-cloud-datastore:2.8.0:2.8.0
+google-cloud-datastore-bom:2.8.0:2.8.0
+proto-google-cloud-datastore-v1:0.99.0:0.99.0
+datastore-v1-proto-client:2.8.0:2.8.0
+proto-google-cloud-datastore-admin-v1:2.8.0:2.8.0
+grpc-google-cloud-datastore-admin-v1:2.8.0:2.8.0