diff --git a/localstack/services/cloudformation/models/s3.py b/localstack/services/cloudformation/models/s3.py
index ad4a7d3e2e9e8..b5bfbcb5c6dea 100644
--- a/localstack/services/cloudformation/models/s3.py
+++ b/localstack/services/cloudformation/models/s3.py
@@ -164,11 +164,15 @@ def _create_bucket(resource_id, resources, resource_type, func, stack_name):
             except ClientError as e:
                 if e.response["Error"]["Message"] == "Not Found":
                     bucket_name = props.get("BucketName")
-                    s3_client.create_bucket(
-                        Bucket=bucket_name,
-                        ACL=convert_acl_cf_to_s3(props.get("AccessControl", "PublicRead")),
-                        CreateBucketConfiguration={"LocationConstraint": aws_stack.get_region()},
-                    )
+                    params = {
+                        "Bucket": bucket_name,
+                        "ACL": convert_acl_cf_to_s3(props.get("AccessControl", "PublicRead")),
+                    }
+                    if aws_stack.get_region() != "us-east-1":
+                        params["CreateBucketConfiguration"] = {
+                            "LocationConstraint": aws_stack.get_region()
+                        }
+                    s3_client.create_bucket(**params)
 
         result = {
             "create": [