diff --git a/.github/workflows/nightlies.yml b/.github/workflows/nightlies.yml
new file mode 100644
index 000000000000..438fe26cb1ce
--- /dev/null
+++ b/.github/workflows/nightlies.yml
@@ -0,0 +1,64 @@
+name: Upload nightly wheels to Anaconda Cloud
+
+on:
+  # Run daily at 1:23 UTC to upload nightly wheels to Anaconda Cloud
+  schedule:
+    - cron: '23 1 * * *'
+  # Run on demand with workflow dispatch
+  workflow_dispatch:
+
+jobs:
+  upload_nightly_wheels:
+    name: Upload nightly wheels to Anaconda Cloud
+    runs-on: ubuntu-latest
+    if: github.repository_owner == 'matplotlib'
+
+    steps:
+      - name: Install Python
+        uses: actions/setup-python@v3
+        with:
+          python-version: '3.x'
+
+      # c.f. https://github.com/actions/download-artifact/issues/3#issuecomment-1017141067
+      - name: Download wheel artifacts from last build on 'main'
+        shell: bash
+        env:
+          GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
+        run: |
+          PROJECT_REPO="matplotlib/matplotlib"
+          BRANCH="main"
+          WORKFLOW_NAME="cibuildwheel.yml"
+          ARTIFACT_NAME="wheels"
+
+          gh run --repo "${PROJECT_REPO}" \
+             list --branch "${BRANCH}" \
+                  --workflow "${WORKFLOW_NAME}" \
+                  --json event,status,databaseId > runs.json
+          # Filter on 'push' events to main (merged PRs) that have completed
+          jq --compact-output \
+            '[ .[] | select(.event == "push") | select(.status == "completed") ]' \
+            runs.json > pushes.json
+          # Get id of latest build of wheels
+          RUN_ID=$(
+            jq --compact-output \
+              'sort_by(.databaseId) | reverse | .[0].databaseId' pushes.json
+          )
+          gh run --repo "${PROJECT_REPO}" \
+             download "${RUN_ID}" --name "${ARTIFACT_NAME}"
+
+          mkdir dist
+          mv *.whl dist/
+          ls -l dist/
+
+      - name: Install anaconda-client
+        run: |
+          python -m pip install --upgrade pip setuptools wheel
+          # c.f. https://github.com/Anaconda-Platform/anaconda-client/issues/540
+          python -m pip install git+https://github.com/Anaconda-Server/anaconda-client
+          python -m pip list
+
+      - name: Upload wheels to Anaconda Cloud as nightlies
+        run: |
+          anaconda --token ${{ secrets.ANACONDA_ORG_UPLOAD_TOKEN }} upload \
+            --user scipy-wheels-nightly \
+            dist/matplotlib-*.whl
diff --git a/doc/users/installing/index.rst b/doc/users/installing/index.rst
index 10431d0cd465..a2ce7cea6790 100644
--- a/doc/users/installing/index.rst
+++ b/doc/users/installing/index.rst
@@ -80,6 +80,20 @@ you can install Matplotlib via your package manager, e.g.:
 
 .. _install_from_source:
 
+==========================
+Installing a nightly build
+==========================
+
+Matplotlib makes nightly development build wheels available on the
+`scipy-wheels-nightly Anaconda Cloud organization
+<https://anaconda.org/scipy-wheels-nightly>`_.
+These wheels can be installed with ``pip`` by specifying scipy-wheels-nightly
+as the package index to query:
+
+.. code-block:: sh
+
+  python -m pip install --upgrade --index-url https://pypi.anaconda.org/scipy-wheels-nightly/simple matplotlib
+
 ======================
 Installing from source
 ======================