diff --git a/lib/matplotlib/axis.py b/lib/matplotlib/axis.py
index d80e7b4dafb9..ba17c634ac5c 100644
--- a/lib/matplotlib/axis.py
+++ b/lib/matplotlib/axis.py
@@ -1333,9 +1333,11 @@ def _update_ticks(self):
     def _get_ticklabel_bboxes(self, ticks, renderer):
         """Return lists of bboxes for ticks' label1's and label2's."""
         return ([tick.label1.get_window_extent(renderer)
-                 for tick in ticks if tick.label1.get_visible()],
+                 for tick in ticks
+                 if tick.label1.get_visible() and tick.label1.get_in_layout()],
                 [tick.label2.get_window_extent(renderer)
-                 for tick in ticks if tick.label2.get_visible()])
+                 for tick in ticks
+                 if tick.label2.get_visible() and tick.label2.get_in_layout()])
 
     def get_tightbbox(self, renderer=None, *, for_layout_only=False):
         """
diff --git a/lib/matplotlib/tests/test_axis.py b/lib/matplotlib/tests/test_axis.py
index 97884a33208f..67d9ed5bde62 100644
--- a/lib/matplotlib/tests/test_axis.py
+++ b/lib/matplotlib/tests/test_axis.py
@@ -2,6 +2,7 @@
 
 import matplotlib.pyplot as plt
 from matplotlib.axis import XTick
+from matplotlib.testing.decorators import check_figures_equal
 
 
 def test_tick_labelcolor_array():
@@ -31,6 +32,21 @@ def test_axis_not_in_layout():
     assert ax1_right.get_position().bounds == ax2_right.get_position().bounds
 
 
+@check_figures_equal()
+def test_tick_not_in_layout(fig_test, fig_ref):
+    # Check that the "very long" ticklabel is ignored from layouting after
+    # set_in_layout(False); i.e. the layout is as if the ticklabel was empty.
+    # Ticklabels are set to white so that the actual string doesn't matter.
+    fig_test.set_layout_engine("constrained")
+    ax = fig_test.add_subplot(xticks=[0, 1], xticklabels=["short", "very long"])
+    ax.tick_params(labelcolor="w")
+    fig_test.draw_without_rendering()  # Ensure ticks are correct.
+    ax.xaxis.majorTicks[-1].label1.set_in_layout(False)
+    fig_ref.set_layout_engine("constrained")
+    ax = fig_ref.add_subplot(xticks=[0, 1], xticklabels=["short", ""])
+    ax.tick_params(labelcolor="w")
+
+
 def test_translate_tick_params_reverse():
     fig, ax = plt.subplots()
     kw = {'label1On': 'a', 'label2On': 'b', 'tick1On': 'c', 'tick2On': 'd'}