Hello,
The PHP extension php_opcache.dll can be enabled through PHPManager, but it enables it with the extension directive, but it's a Zend extension and should be enabled through the zend_extension directive, otherwise, the following error is shown at PHP error log:

PHP Warning: PHP Startup: Invalid library (appears to be a Zend Extension, try loading using zend_extension=php_opcache.dll from php.ini) in Unknown on line 0