diff --git a/Lib/test/test_sqlite3/test_dbapi.py b/Lib/test/test_sqlite3/test_dbapi.py
index 9d94ddda95bd4d..899f5cfbd31969 100644
--- a/Lib/test/test_sqlite3/test_dbapi.py
+++ b/Lib/test/test_sqlite3/test_dbapi.py
@@ -1461,6 +1461,14 @@ def test_blob_closed_db_read(self):
                                    "Cannot operate on a closed database",
                                    blob.read)
 
+    def test_blob_32bit_rowid(self):
+        # gh-100370: we should not get an OverflowError for 32-bit rowids
+        with memory_database() as cx:
+            rowid = 2**32
+            cx.execute("create table t(t blob)")
+            cx.execute("insert into t(rowid, t) values (?, zeroblob(1))", (rowid,))
+            cx.blobopen('t', 't', rowid)
+
 
 @threading_helper.requires_working_threading()
 class ThreadTests(unittest.TestCase):
diff --git a/Misc/NEWS.d/next/Library/2023-04-27-00-45-41.gh-issue-100370.MgZ3KY.rst b/Misc/NEWS.d/next/Library/2023-04-27-00-45-41.gh-issue-100370.MgZ3KY.rst
new file mode 100644
index 00000000000000..9022d55c48cb11
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2023-04-27-00-45-41.gh-issue-100370.MgZ3KY.rst
@@ -0,0 +1,2 @@
+Fix potential :exc:`OverflowError` in :meth:`sqlite3.Connection.blobopen`
+for 32-bit builds. Patch by Erlend E. Aasland.
diff --git a/Modules/_sqlite/clinic/connection.c.h b/Modules/_sqlite/clinic/connection.c.h
index 62d31b787ad717..4bdf98b6933e4f 100644
--- a/Modules/_sqlite/clinic/connection.c.h
+++ b/Modules/_sqlite/clinic/connection.c.h
@@ -162,7 +162,7 @@ PyDoc_STRVAR(blobopen__doc__,
 
 static PyObject *
 blobopen_impl(pysqlite_Connection *self, const char *table, const char *col,
-              int row, int readonly, const char *name);
+              sqlite3_int64 row, int readonly, const char *name);
 
 static PyObject *
 blobopen(pysqlite_Connection *self, PyObject *const *args, Py_ssize_t nargs, PyObject *kwnames)
@@ -174,7 +174,7 @@ blobopen(pysqlite_Connection *self, PyObject *const *args, Py_ssize_t nargs, PyO
     Py_ssize_t noptargs = nargs + (kwnames ? PyTuple_GET_SIZE(kwnames) : 0) - 3;
     const char *table;
     const char *col;
-    int row;
+    sqlite3_int64 row;
     int readonly = 0;
     const char *name = "main";
 
@@ -208,8 +208,7 @@ blobopen(pysqlite_Connection *self, PyObject *const *args, Py_ssize_t nargs, PyO
         PyErr_SetString(PyExc_ValueError, "embedded null character");
         goto exit;
     }
-    row = _PyLong_AsInt(args[2]);
-    if (row == -1 && PyErr_Occurred()) {
+    if (!sqlite3_int64_converter(args[2], &row)) {
         goto exit;
     }
     if (!noptargs) {
@@ -1237,4 +1236,4 @@ getlimit(pysqlite_Connection *self, PyObject *arg)
 #ifndef DESERIALIZE_METHODDEF
     #define DESERIALIZE_METHODDEF
 #endif /* !defined(DESERIALIZE_METHODDEF) */
-/*[clinic end generated code: output=8818c1c3ec9425aa input=a9049054013a1b77]*/
+/*[clinic end generated code: output=67e5b3dbade4a15b input=a9049054013a1b77]*/
diff --git a/Modules/_sqlite/connection.c b/Modules/_sqlite/connection.c
index 20982558840bbf..9c7eb85df3b747 100644
--- a/Modules/_sqlite/connection.c
+++ b/Modules/_sqlite/connection.c
@@ -92,6 +92,20 @@ isolation_level_converter(PyObject *str_or_none, const char **result)
     return 1;
 }
 
+static int
+sqlite3_int64_converter(PyObject *obj, sqlite3_int64 *result)
+{
+    if (!PyLong_Check(obj)) {
+        PyErr_SetString(PyExc_TypeError, "expected 'int'");
+        return 0;
+    }
+    *result = _pysqlite_long_as_int64(obj);
+    if (PyErr_Occurred()) {
+        return 0;
+    }
+    return 1;
+}
+
 #define clinic_state() (pysqlite_get_state_by_type(Py_TYPE(self)))
 #include "clinic/connection.c.h"
 #undef clinic_state
@@ -137,8 +151,12 @@ class IsolationLevel_converter(CConverter):
     type = "const char *"
     converter = "isolation_level_converter"
 
+class sqlite3_int64_converter(CConverter):
+    type = "sqlite3_int64"
+    converter = "sqlite3_int64_converter"
+
 [python start generated code]*/
-/*[python end generated code: output=da39a3ee5e6b4b0d input=cbcfe85b253061c2]*/
+/*[python end generated code: output=da39a3ee5e6b4b0d input=e9bee126e0500e61]*/
 
 // NB: This needs to be in sync with the sqlite3.connect docstring
 /*[clinic input]
@@ -401,7 +419,7 @@ _sqlite3.Connection.blobopen as blobopen
         Table name.
     column as col: str
         Column name.
-    row: int
+    row: sqlite3_int64
         Row index.
     /
     *
@@ -415,8 +433,8 @@ Open and return a BLOB object.
 
 static PyObject *
 blobopen_impl(pysqlite_Connection *self, const char *table, const char *col,
-              int row, int readonly, const char *name)
-/*[clinic end generated code: output=0c8e2e58516d0b5c input=1e7052516acfc94d]*/
+              sqlite3_int64 row, int readonly, const char *name)
+/*[clinic end generated code: output=6a02d43efb885d1c input=4180b11a0591d80d]*/
 {
     if (!pysqlite_check_thread(self) || !pysqlite_check_connection(self)) {
         return NULL;