diff --git a/Lib/subprocess.py b/Lib/subprocess.py
index 696617697047d2..741cc4a5bb324f 100644
--- a/Lib/subprocess.py
+++ b/Lib/subprocess.py
@@ -1390,6 +1390,10 @@ def _get_handles(self, stdin, stdout, stderr):
                     errread, errwrite)
 
 
+        def _posix_spawn(self, args, executable):
+            """Execute program using os.posix_spawn()."""
+            self.pid = os.posix_spawn(executable, args, os.environ)
+
         def _execute_child(self, args, executable, preexec_fn, close_fds,
                            pass_fds, cwd, env,
                            startupinfo, creationflags, shell,
@@ -1414,6 +1418,21 @@ def _execute_child(self, args, executable, preexec_fn, close_fds,
 
             if executable is None:
                 executable = args[0]
+
+            if (os.path.dirname(executable)
+                    and preexec_fn is None
+                    and not close_fds
+                    and not pass_fds
+                    and cwd is None
+                    and env is None
+                    and p2cread == p2cwrite == -1
+                    and c2pread == c2pwrite == -1
+                    and errread == errwrite == -1
+                    and not restore_signals
+                    and not start_new_session):
+                self._posix_spawn(args, executable)
+                return
+
             orig_executable = executable
 
             # For transferring possible exec failure from child to parent.
diff --git a/Misc/NEWS.d/next/Library/2018-12-20-16-24-51.bpo-35537.z4E7aA.rst b/Misc/NEWS.d/next/Library/2018-12-20-16-24-51.bpo-35537.z4E7aA.rst
new file mode 100644
index 00000000000000..e86c3ab7fd16ea
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2018-12-20-16-24-51.bpo-35537.z4E7aA.rst
@@ -0,0 +1 @@
+subprocess.Popen can now use posix_spawn() in some cases.
\ No newline at end of file