diff --git a/Misc/NEWS.d/next/Windows/2025-05-07-11-45-30.gh-issue-133572.Xc2zxH.rst b/Misc/NEWS.d/next/Windows/2025-05-07-11-45-30.gh-issue-133572.Xc2zxH.rst
new file mode 100644
index 00000000000000..993eceab0b79c2
--- /dev/null
+++ b/Misc/NEWS.d/next/Windows/2025-05-07-11-45-30.gh-issue-133572.Xc2zxH.rst
@@ -0,0 +1 @@
+Avoid LsaNtStatus to WinError conversion on unsupported WinAPI partitions.
diff --git a/Modules/mmapmodule.c b/Modules/mmapmodule.c
index 6a385562845849..7c4eb05488eb33 100644
--- a/Modules/mmapmodule.c
+++ b/Modules/mmapmodule.c
@@ -290,6 +290,24 @@ filter_page_exception_method(mmap_object *self, EXCEPTION_POINTERS *ptrs,
     }
     return EXCEPTION_CONTINUE_SEARCH;
 }
+
+static void
+_PyErr_SetFromNTSTATUS(ULONG status)
+{
+#if defined(MS_WINDOWS_DESKTOP) || defined(MS_WINDOWS_SYSTEM)
+    PyErr_SetFromWindowsErr(LsaNtStatusToWinError((NTSTATUS)status));
+#else
+    if (status & 0x80000000) {
+        // HRESULT-shaped codes are supported by PyErr_SetFromWindowsErr
+        PyErr_SetFromWindowsErr((int)status);
+    }
+    else {
+        // No mapping for NTSTATUS values, so just return it for diagnostic purposes
+        // If we provide it as winerror it could incorrectly change the type of the exception.
+        PyErr_Format(PyExc_OSError, "Operating system error NTSTATUS=0x%08lX", status);
+    }
+#endif
+}
 #endif
 
 #if defined(MS_WINDOWS) && !defined(DONT_USE_SEH)
@@ -303,9 +321,7 @@ do {                                                                       \
         assert(record.ExceptionCode == EXCEPTION_IN_PAGE_ERROR ||          \
                record.ExceptionCode == EXCEPTION_ACCESS_VIOLATION);        \
         if (record.ExceptionCode == EXCEPTION_IN_PAGE_ERROR) {             \
-            NTSTATUS status = (NTSTATUS) record.ExceptionInformation[2];   \
-            ULONG code = LsaNtStatusToWinError(status);                    \
-            PyErr_SetFromWindowsErr(code);                                 \
+            _PyErr_SetFromNTSTATUS((ULONG)record.ExceptionInformation[2]); \
         }                                                                  \
         else if (record.ExceptionCode == EXCEPTION_ACCESS_VIOLATION) {     \
             PyErr_SetFromWindowsErr(ERROR_NOACCESS);                       \
@@ -332,9 +348,7 @@ do {                                                                          \
         assert(record.ExceptionCode == EXCEPTION_IN_PAGE_ERROR ||             \
                record.ExceptionCode == EXCEPTION_ACCESS_VIOLATION);           \
         if (record.ExceptionCode == EXCEPTION_IN_PAGE_ERROR) {                \
-            NTSTATUS status = (NTSTATUS) record.ExceptionInformation[2];      \
-            ULONG code = LsaNtStatusToWinError(status);                       \
-            PyErr_SetFromWindowsErr(code);                                    \
+            _PyErr_SetFromNTSTATUS((ULONG)record.ExceptionInformation[2]);    \
         }                                                                     \
         else if (record.ExceptionCode == EXCEPTION_ACCESS_VIOLATION) {        \
             PyErr_SetFromWindowsErr(ERROR_NOACCESS);                          \