diff --git a/Lib/re/_constants.py b/Lib/re/_constants.py
index c45ce409e21b85..71204d903b3226 100644
--- a/Lib/re/_constants.py
+++ b/Lib/re/_constants.py
@@ -62,6 +62,8 @@ def __new__(cls, value, name):
     def __repr__(self):
         return self.name
 
+    __reduce__ = None
+
 MAXREPEAT = _NamedIntConstant(MAXREPEAT, 'MAXREPEAT')
 
 def _makecodes(*names):
diff --git a/Misc/NEWS.d/next/Library/2022-04-30-10-53-10.gh-issue-92049.5SEKoh.rst b/Misc/NEWS.d/next/Library/2022-04-30-10-53-10.gh-issue-92049.5SEKoh.rst
new file mode 100644
index 00000000000000..cad4621c65096c
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-04-30-10-53-10.gh-issue-92049.5SEKoh.rst
@@ -0,0 +1,2 @@
+Forbid pickling constants ``re._constants.SUCCESS`` etc. Previously,
+pickling did not fail, but the result could not be unpickled.