diff --git a/mypy/stubtest.py b/mypy/stubtest.py
index e67992ace5f8..546ea96dd9a0 100644
--- a/mypy/stubtest.py
+++ b/mypy/stubtest.py
@@ -676,6 +676,18 @@ def _verify_signature(
         yield 'runtime does not have **kwargs argument "{}"'.format(stub.varkw.variable.name)
 
 
+def _verify_coroutine(
+    stub: nodes.FuncItem, runtime: Any, *, runtime_is_coroutine: bool
+) -> Optional[str]:
+    if stub.is_coroutine:
+        if not runtime_is_coroutine:
+            return 'is an "async def" function in the stub, but not at runtime'
+    else:
+        if runtime_is_coroutine:
+            return 'is an "async def" function at runtime, but not in the stub'
+    return None
+
+
 @verify.register(nodes.FuncItem)
 def verify_funcitem(
     stub: nodes.FuncItem, runtime: MaybeMissing[Any], object_path: List[str]
@@ -693,19 +705,40 @@ def verify_funcitem(
         yield Error(object_path, "is inconsistent, " + message, stub, runtime)
 
     signature = safe_inspect_signature(runtime)
+    runtime_is_coroutine = inspect.iscoroutinefunction(runtime)
+
+    if signature:
+        stub_sig = Signature.from_funcitem(stub)
+        runtime_sig = Signature.from_inspect_signature(signature)
+        runtime_sig_desc = f'{"async " if runtime_is_coroutine else ""}def {signature}'
+    else:
+        runtime_sig_desc = None
+
+    coroutine_mismatch_error = _verify_coroutine(
+        stub,
+        runtime,
+        runtime_is_coroutine=runtime_is_coroutine
+    )
+
+    if coroutine_mismatch_error is not None:
+        yield Error(
+            object_path,
+            coroutine_mismatch_error,
+            stub,
+            runtime,
+            runtime_desc=runtime_sig_desc
+        )
+
     if not signature:
         return
 
-    stub_sig = Signature.from_funcitem(stub)
-    runtime_sig = Signature.from_inspect_signature(signature)
-
     for message in _verify_signature(stub_sig, runtime_sig, function_name=stub.name):
         yield Error(
             object_path,
             "is inconsistent, " + message,
             stub,
             runtime,
-            runtime_desc="def " + str(signature),
+            runtime_desc=runtime_sig_desc,
         )
 
 
diff --git a/mypy/test/teststubtest.py b/mypy/test/teststubtest.py
index 2852299548ed..78ae82b058cd 100644
--- a/mypy/test/teststubtest.py
+++ b/mypy/test/teststubtest.py
@@ -28,6 +28,34 @@ def use_tmp_dir() -> Iterator[None]:
 
 TEST_MODULE_NAME = "test_module"
 
+
+stubtest_typing_stub = """
+Any = object()
+
+class _SpecialForm:
+    def __getitem__(self, typeargs: Any) -> object: ...
+
+Callable: _SpecialForm = ...
+Generic: _SpecialForm = ...
+
+class TypeVar:
+    def __init__(self, name, covariant: bool = ..., contravariant: bool = ...) -> None: ...
+
+_T = TypeVar("_T")
+_T_co = TypeVar("_T_co", covariant=True)
+_K = TypeVar("_K")
+_V = TypeVar("_V")
+_S = TypeVar("_S", contravariant=True)
+_R = TypeVar("_R", covariant=True)
+
+class Coroutine(Generic[_T_co, _S, _R]): ...
+class Iterable(Generic[_T_co]): ...
+class Mapping(Generic[_K, _V]): ...
+class Sequence(Iterable[_T_co]): ...
+class Tuple(Sequence[_T_co]): ...
+def overload(func: _T) -> _T: ...
+"""
+
 stubtest_builtins_stub = """
 from typing import Generic, Mapping, Sequence, TypeVar, overload
 
@@ -66,6 +94,8 @@ def run_stubtest(
     with use_tmp_dir():
         with open("builtins.pyi", "w") as f:
             f.write(stubtest_builtins_stub)
+        with open("typing.pyi", "w") as f:
+            f.write(stubtest_typing_stub)
         with open("{}.pyi".format(TEST_MODULE_NAME), "w") as f:
             f.write(stub)
         with open("{}.py".format(TEST_MODULE_NAME), "w") as f:
@@ -172,6 +202,29 @@ class X:
             error="X.mistyped_var",
         )
 
+    @collect_cases
+    def test_coroutines(self) -> Iterator[Case]:
+        yield Case(
+            stub="async def foo() -> int: ...",
+            runtime="def foo(): return 5",
+            error="foo",
+        )
+        yield Case(
+            stub="def bar() -> int: ...",
+            runtime="async def bar(): return 5",
+            error="bar",
+        )
+        yield Case(
+            stub="def baz() -> int: ...",
+            runtime="def baz(): return 5",
+            error=None,
+        )
+        yield Case(
+            stub="async def bingo() -> int: ...",
+            runtime="async def bingo(): return 5",
+            error=None,
+        )
+
     @collect_cases
     def test_arg_name(self) -> Iterator[Case]:
         yield Case(