diff --git a/clr_loader/__init__.py b/clr_loader/__init__.py
index d0d8ff2..4b08148 100644
--- a/clr_loader/__init__.py
+++ b/clr_loader/__init__.py
@@ -30,6 +30,9 @@ def get_mono(
     sgen: bool = True,
     debug: bool = False,
     jit_options: Optional[Sequence[str]] = None,
+    assembly_dir: Optional[str] = None,
+    config_dir: Optional[str] = None,
+    set_signal_chaining: bool = False
 ) -> Runtime:
     """Get a Mono runtime instance
 
@@ -48,6 +51,20 @@ def get_mono(
         Whether to initialise Mono debugging
     :param jit_options:
         "Command line options" passed to Mono's ``mono_jit_parse_options``
+    :param assembly_dir:
+        The base directory for assemblies, passed to ``mono_set_dirs``
+    :param config_dir:
+        The base directory for configuration files, passed to ``mono_set_dirs``
+    :param set_signal_chaining:
+        Whether to enable signal chaining, passed to ``mono_set_signal_chaining``.
+        If it is enabled, the runtime saves the original signal handlers before
+        installing its own, and calls the original ones in the following cases:
+            - SIGSEGV/SIGABRT while executing native code
+            - SIGPROF
+            - SIGFPE
+            - SIGQUIT
+            - SIGUSR2
+        This currently only works on POSIX platforms
     """
     from .mono import Mono
 
@@ -62,6 +79,9 @@ def get_mono(
         config_file=_maybe_path(config_file),
         global_config_file=_maybe_path(global_config_file),
         libmono=libmono,
+        assembly_dir=assembly_dir,
+        config_dir=config_dir,
+        set_signal_chaining=set_signal_chaining,
     )
     return impl
 
diff --git a/clr_loader/ffi/mono.py b/clr_loader/ffi/mono.py
index ed48cff..c194393 100644
--- a/clr_loader/ffi/mono.py
+++ b/clr_loader/ffi/mono.py
@@ -39,5 +39,10 @@
 MonoObject* mono_runtime_invoke(MonoMethod *method, void *obj, void **params, MonoObject **exc);
 
 void* mono_object_unbox(MonoObject *object);
+
+void mono_set_dirs(const char *assembly_dir, const char* config_dir);
+
+void mono_set_signal_chaining(bool chain_signals);
+
 """
 )
diff --git a/clr_loader/mono.py b/clr_loader/mono.py
index fb8ab1b..158ddb7 100644
--- a/clr_loader/mono.py
+++ b/clr_loader/mono.py
@@ -24,6 +24,9 @@ def __init__(
         jit_options: Optional[Sequence[str]] = None,
         config_file: Optional[Path] = None,
         global_config_file: Optional[Path] = None,
+        assembly_dir: Optional[str] = None,
+        config_dir: Optional[str] = None,
+        set_signal_chaining: bool = False,
     ):
         self._assemblies: Dict[Path, Any] = {}
 
@@ -33,6 +36,9 @@ def __init__(
             jit_options=jit_options,
             global_config_file=optional_path_as_string(global_config_file),
             libmono=libmono,
+            assembly_dir=assembly_dir,
+            config_dir=config_dir,
+            set_signal_chaining=set_signal_chaining,
         )
 
         if domain is None:
@@ -121,11 +127,17 @@ def initialize(
     jit_options: Optional[Sequence[str]] = None,
     config_file: Optional[str] = None,
     global_config_file: Optional[str] = None,
+    assembly_dir: Optional[str] = None,
+    config_dir: Optional[str] = None,
+    set_signal_chaining: bool = False,
 ) -> str:
     global _MONO, _ROOT_DOMAIN
     if _MONO is None:
         _MONO = load_mono(libmono)
 
+        if assembly_dir is not None and config_dir is not None:
+            _MONO.mono_set_dirs(assembly_dir, config_dir)
+
         # Load in global config (i.e /etc/mono/config)
         global_encoded = global_config_file or ffi.NULL
         _MONO.mono_config_parse(global_encoded)
@@ -143,6 +155,9 @@ def initialize(
         else:
             options = []
 
+        if set_signal_chaining:
+            _MONO.mono_set_signal_chaining(True)
+
         if debug:
             _MONO.mono_debug_init(_MONO.MONO_DEBUG_FORMAT_MONO)
 
diff --git a/tests/test_common.py b/tests/test_common.py
index 5e5338d..f42020a 100644
--- a/tests/test_common.py
+++ b/tests/test_common.py
@@ -46,6 +46,21 @@ def test_mono_debug(example_netstandard):
 
     run_tests(asm)
 
+def test_mono_signal_chaining(example_netstandard):
+    from clr_loader import get_mono
+
+    mono = get_mono(set_signal_chaining=True)
+    asm = mono.get_assembly(example_netstandard / "example.dll")
+
+    run_tests(asm)
+
+def test_mono_set_dir(example_netstandard):
+    from clr_loader import get_mono
+
+    mono = get_mono(assembly_dir="/usr/lib", config_dir="/etc")
+    asm = mono.get_assembly(example_netstandard / "example.dll")
+
+    run_tests(asm)
 
 def test_coreclr(example_netcore):
     from clr_loader import get_coreclr