If you read the docs you can see that pythonnet is only working for <=Python3.8.

#1389

Well, the master branch (that the pythonnet-3.0 is built from) should support 3.9 and 3.10, but I can't reproduce this particular error.

It could matter in the sense that I don't have a 32bit system to test with, so I can just test a 64bit Windows with a 32bit Python installation, and that doesn't exhibit the problem that you are seeing.

It could be that this was fixed in pythonnet/clr-loader#15, so clr-loader 0.1.7. Please try to upgrade this package (pip install -U clr-loader) and reopen if that doesn't fix the issue.

Still has same problem 32bit Windows 10
Python 3.10.0
Clr_loader 0.1.7

update .NET and solved.

update .NET and solved.

could you pls share you address this issue with more details,
i still have this issue and pending my development for days..
File "C:\Users\XXX\AppData\Local\Programs\Python\Python310\lib\site-packages\pythonnet\__init__.py", line 143, in load if func(b"") != 0: File "C:\Users\XXX\AppData\Local\Programs\Python\Python310\lib\site-packages\clr_loader\types.py", line 64, in __call__ return self._callable(ffi.cast("void*", buf_arr), len(buf_arr)) RuntimeError: cannot call null pointer pointer from cdata 'int(*)(void *, int)'

Hi, did you solve the problem?
I am using :
python 3.7.11
windows 10 64bits
Clr_loader 0.1.7

everything is okay while running in pycharm, but after I pack up the script in pyinstaller, I got the error:

cannot load library ...\clr_loader\ffi\dlls\amd64\ClrLoader.dll': error 0x7e

after I copy the clr_loader folder to the project folder, I got the same error :

File "", line 983, in _find_and_load
File "", line 967, in _find_and_load_unlocked
File "", line 677, in load_unlocked
File "PyInstaller\loader\pyimod03_importers.py", line 495, in exec_module
File "clr.py", line 6, in
File "pythonnet_init.py", line 143, in load
File "clr_loader\types.py", line 64, in call
return self._callable(ffi.cast("void*", buf_arr), len(buf_arr))
RuntimeError: cannot call null pointer pointer from cdata 'int(*)(void *, int)'

I am seeing this issue with pyinstaller on python3.9; @tony950309 were you able to find a workaround?

I also get the same error after building with pyinstaller:
clr-loader 0.2.5
pythonnet 3.0.1
python 3.10.10

I have no idea what the problem is, since it works on my win11 machine, but won't on another and I did not install any additional .NET dependencies.

Is there a workaround? Or do you need more info? I see this issue is closed, but seems to be an ongoing problem.

The problem seems to be related to an outdated hook-clr.py from pyinstaller-hooks-contrib, updating pyinstaller-hooks-contrib solved my problem.

pip install --upgrade --force-reinstall pyinstaller-hooks-contrib

I faced this problem in venv,without venv no problem,and nothing to do with py310 or py311