uninstall:

rmdir /S /Q  C:\dest_dir

remove package sqlite_bro (for example):

pip uninstall --y sqlite_bro

install (silent) for all users?
That's not a suggested feature, unless everyone trust everyone in your context:

• install it on a shared directory.
• make user settings separated by removing all the "#" character in the default settings\winpython.ini file as follow:
  BEFORE:

[debug]
state = disabled
[environment]
#HOME = %HOMEDRIVE%%HOMEPATH%\Documents\WinPython%WINPYVER%
#JUPYTER_DATA_DIR = %HOME%
#WINPYWORKDIR = %HOMEDRIVE%%HOMEPATH%\Documents\WinPython%WINPYVER%\Notebooks

AFTER:

[debug]
state = disabled
[environment]
HOME = %HOMEDRIVE%%HOMEPATH%\Documents\WinPython%WINPYVER%
JUPYTER_DATA_DIR = %HOME%
WINPYWORKDIR = %HOMEDRIVE%%HOMEPATH%\Documents\WinPython%WINPYVER%\Notebooks

... with all the Jupyterlab story, maybe this procedure is no longer valid/sufficient, and a fully separated winpython copy per user account the best solution.
(duplicate N times your reference WinPython directory)