Brain response to command can be detected using task-based EEG. Insufficient evidence of brain response and prognosis remain happen in brain infarction. This preliminary study aimed to explore brain response in task-based electroencephalography (EEG) and the 6-month responsiveness in brain infarction. Interestingly, we detected brain response in 58.59% of clinically responsive patients and 6.25% of unresponsive patients. The presence of brain response in clinically unresponsive patient indicates brain activation despite the absence of responsiveness in Glasgow Coma Scale (GCS) assessment. This descriptive and comparison analysis highlights the utility of EEG-based machine learning to identify brain response in brain infarction patients, providing insights for further investigation related to brain injury prognosis, rehabilitation strategy, and management.