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HSP60/YLR259C Summary Help


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HSP60 BASIC INFORMATION

Standard Name HSP60
Systematic Name YLR259C
Alias CPN60, MIF4
Feature Type ORF, Verified
Description Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated (1, 2, 3, 4, 5, 6)
Name Description Heat Shock Protein 3, 7
GO Annotations All HSP60 GO evidence and references
    View Computational GO annotations for HSP60
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype HSP60 Phenotype details and references
Order mutant strains used in systematic deletion project
Systematic deletion
  • inviable
Null
  • inviable
Interactions HSP60 All interactions details and references
Physical Interactions HSP60 Physical Interactions details and references
Affinity Capture-MS There are 37 total Affinity Capture-MS interactions
Affinity Capture-Western There is 1 total Affinity Capture-Western interactions
Biochemical Activity There are 3 total Biochemical Activity interactions
Co-purification There is 1 total Co-purification interactions
Reconstituted Complex There is 1 total Reconstituted Complex interactions
Two-hybrid There is 1 total Two-hybrid interactions
Genetic Interactions HSP60 Genetic Interactions details and references
Synthetic Lethality There are 2 total Synthetic Lethality interactions resulting in the following phenotype: inviable
Sequence Information
ChrXII:665004 to 663286 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
GBrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1719 665004..663286 2004-02-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProt/Swiss-Prot
Primary SGDIDS000004249

HSP60 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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Expression Summary histogram

ADDITIONAL INFORMATION for HSP60

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HSP60]

1) Cheng MY, et al.  (1990) The mitochondrial chaperonin hsp60 is required for its own assembly. Nature 348(6300):455-8
2) Koll H, et al.  (1992) Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. Cell 68(6):1163-75
3) Reading DS, et al.  (1989) Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor. Nature 337(6208):655-9
4) Cheng MY, et al.  (1989) Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337(6208):620-5
5) Kaufman BA, et al.  (2003) A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae. J Cell Biol 163(3):457-61
6) Reinders J, et al.  (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
7) Johnson RB, et al.  (1989) Cloning and characterization of the yeast chaperonin HSP60 gene. Gene 84(2):295-302