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Pulmonary Function and Circulation Guide

The document discusses pulmonary physiology including: 1. Flow-volume loops and measurements of resistance, lung volumes, and tests of flow limitation like FEV1 and FEF. 2. The pulmonary circulation, including its roles in gas and fluid exchange, and measurements of pressures, resistance, and regional flow. 3. Oxygen transport, including components of blood like hemoglobin and mechanisms of oxygen carrying like the oxyhemoglobin dissociation curve and Bohr shift. Carbon dioxide transport is also mentioned.

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mange24
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339 views50 pages

Pulmonary Function and Circulation Guide

The document discusses pulmonary physiology including: 1. Flow-volume loops and measurements of resistance, lung volumes, and tests of flow limitation like FEV1 and FEF. 2. The pulmonary circulation, including its roles in gas and fluid exchange, and measurements of pressures, resistance, and regional flow. 3. Oxygen transport, including components of blood like hemoglobin and mechanisms of oxygen carrying like the oxyhemoglobin dissociation curve and Bohr shift. Carbon dioxide transport is also mentioned.

Uploaded by

mange24
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
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Flow Volume Loop

Resistance = P/flow

FRC

ours have normal


circles or error bars
or normal curve
Flow Volume Loop
Flow Volume Loop
Expiratory flow limitation - Choke point
Resistance
Volume effects on vasculature and airways
Tethering
Tests of flow limitation

FEV1
FEF 25-75
FEV1/FVC
Obstruction/Restriction

Normal
Asthma
COPD
Restriction
Lung Volumes
Lung Volumes
Measurement of FRC
Overview of System
Pulmonary Circulation
Pulmonary Circulation
Pulmonary Circulation

1. Gas exchange
2. Fluid exchange
3. Reservoir for LV
4. Nutrition
5. Filter
Pulmonary circulation

collateral flow from systemic system


Pulmonary Pressures

1. Absolute intravascular pressure


2. Transmural pressure
3. Driving pressure
4. Relation to pre-load
Resistance in pulmonary vasculature
Measurements

Pre-load
Pulmonary artery catheter
Cardiac output
Regional flow

watch H2O to Hg
Regional Flow
WEST Zones
WEST Zones
Volume effects on vasculature
Volume effects on vasculature
Zones for real
Hypoxic effects
Fluid balance
Starling relations
.
Qf = Kf [(Pmv-Ppmv)-(mv-pmv)]
10-(-3) - .75(25-16)
13 - 7 = 6 mL H2O/min/mm Hg/unit area
Pulmonary Edema

high vs low pressure

capillary pres

membrane

protein in alv fluid

repair
Overview of System
Oxygen Transport

Fe = location of O2 binding
Hgb = 1/4 RBC volume
= drop organelles O2 shift -  color
= 140 day T1/2 - cooximeter
Hct = Vol/Vol %
Blood
Oxygen content
Oxygen content
CaO2 = (0.003 PO2 )+ (1.34xHgbxSat)
Oxy-Hgb Saturation Curve
Bohr Shift
Fick Principle

O2 use = Flow x (O2 upstream - O2 downstream)


Carbon Dioxide

H2O + CO2  H+ + HCO3-


Haldane effect

1. CO2XHgbdeoxy
2. H+ better to Hgbdeoxy
H2O + CO2H+ + HCO3-
to right
1. 2.

3.

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