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Biotech Drugs - Introduction To Drug Discovery

Drug discovery begins with identifying candidate molecules that can interact with biological targets in the body. Traditional drug discovery relied on chemistry to develop small molecule drugs, while modern approaches utilize molecular biology and high-throughput screening to develop biotech drugs like monoclonal antibodies. Successful drug candidates must be safe, potent, stable, deliverable to the target site of action, accessible through isolation or synthesis, and patentable. Advances in molecular biology, high-throughput screening, and pharmacogenetics have improved understanding of disease processes and enabled discovery of new drugs tailored to individual genetics.

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47 views2 pages

Biotech Drugs - Introduction To Drug Discovery

Drug discovery begins with identifying candidate molecules that can interact with biological targets in the body. Traditional drug discovery relied on chemistry to develop small molecule drugs, while modern approaches utilize molecular biology and high-throughput screening to develop biotech drugs like monoclonal antibodies. Successful drug candidates must be safe, potent, stable, deliverable to the target site of action, accessible through isolation or synthesis, and patentable. Advances in molecular biology, high-throughput screening, and pharmacogenetics have improved understanding of disease processes and enabled discovery of new drugs tailored to individual genetics.

Uploaded by

DelbertWebster
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Biotech Drugs - Introduction to Drug

Discovery
Drug Finding - Introduction
The Drug business is one of many important participants active in the development of the field of
bioinformatics. Many pharmaceutical organizations have inner teams conducting bioinformatics
research. The pharmaceutical market represents an important position in the orld economy. The
main function is to create another important drug. Many Drugs are little molecules that are
created to bind! interact! and modulate the game of particular scientific receptors.
Drug discovery - Traditional perspective
Drug study began as an e"tension of chemistry about a century ago. In #$%&! 'ekule produce the
theory of aromatic natural molecules. (enry )hlrich used the particular affinity of colors for
biological areas to postulate the e"istence of *hemoreceptors. This generated birth of
*hemotherapy - some sort of Drug treatment. +harmacology produced a s a different supply
because of the attempts of ,sald -chmiedeberg at the university of pharmacology beteen
#$.# and #/#$. +enicillin as found by 0le"ander Fleming in #/1/. The characterization of
*arboanhydrase in #/22 as accompanied by the finding of -ulphanilamide.
Drug - )"planation
0 Drug is a molecule that interacts ith a goal biological molecule in the body and trough such
relationship causes a physiological effect.
-ubstance substance as Drug
0 chemical ingredient to 3ualify as a Drug needs to have these faculties4
It must be
-ecure
+oerful
-table 5both chemically and metabolically6
Deliverable 5should be absorbed and must reach the site of action6
0ccessible 5by isolation or by synthesis6
Book 5patentable6
+laces influencing Drug Discovery
There are several techni3ues to discover ne drugs. They vary from Molecular biology to
*ombinatorial *hemistry.
0 fe of the methods are the folloing4-
Impact of molecular biology on Drug Finding4
Molecular biology has profound impact in Drug Discovery. It applies the concept of genetic
information to biochemical and compound pathays. The protein Drugs such as for instance
7ecombinant meats and Monoclonal antibodies are named as 8Biotech Drugs.8 Molecular
biology may also support people to understand condition procedures at molecular or genetic
level and to find out optimum molecular goals for Drug intervention.
(igh -Throughput 9erification 5(T-64
In this approach of Drug finding! many hypothetical targets are integrated into in-vitro or mobile
based assays and confronted ith large amount of ingredients representing numerous
modifications on several compound themes.
+harmacogenetic )ngineering4
+harmacogenetics is the research of heritable schedule for differences in a population.
+harmacogenetics makes considerable use of automatic methods for protein and gene
se3uencing. The D:0 se3uences of individual genome are not identical and vary from specific to
individual. +harmacogenetics is ergo centered on recognition of genetic modifications
5polymorphisms6 that transform Drug concentrations and responses for ;-07.
7ealization
The decades of medical e"amine in the sub<ect of pharmacology! molecular biology and
biotechnology has led to the procedure of development of ne drugs.

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